シミズ　タツヤ   SHIMIZU Tatsuya   清水　達也    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	The heterogeneity of dermal mesenchymal cells reproduced in skin equivalents regulates barrier function and elasticity.
掲載誌名	正式名：EMBO reports 略　 称：EMBO Rep ISSNコード：14693178/1469221X
掲載区分	国外
巻・号・頁	pp.Online ahead of print
著者・共著者	KIMURA Shun, SEKIYA Sachiko, YAMASHIRO　Sawa, KIKUCHI Tetsutaro, HAGA Masatoshi, SHIMIZU Tatsuya
担当区分	最終著者
発行年月	2026/04
概要	The heterogeneity of dermal mesenchymal cells, including perivascular mesenchymal cells and papillary and reticular fibroblasts, plays critical roles in skin homeostasis. Herein, we present human skin equivalents (HSEs), in which pericytes, papillary fibroblasts, and reticular fibroblasts are spatially organized through autonomous three-cell interactions among epidermal keratinocytes, dermal fibroblasts, and vascular endothelial cells. The replication of dermal mesenchymal cell heterogeneity enhances skin functions, including epithelialization, epidermal barrier formation, and dermal elasticity, enabling in vitro evaluation of drug efficacy. Furthermore, ascorbic acid-induced epidermal turnover and synthesis of well-aligned extracellular matrix via perivascular niche cells play crucial roles in improving skin barrier function and elasticity. Therefore, HSEs with heterogeneous dermal mesenchymal cells may improve our understanding of the mechanisms underlying skin homeostasis through cell-to-cell communication and serve as a model to animal experiments for developing precision medicine.
DOI	10.1038/s44319-026-00757-w
PMID	41922844