モリモト　サトシ   MORIMOTO Satoshi   森本　聡    所属   医学部 医学科（附属足立医療センター）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Hypertension and risk of cancer recurrence in adult survivors: A systematic review and meta-analysis.
掲載誌名	正式名：Hypertension research : official journal of the Japanese Society of Hypertension 略　 称：Hypertens Res ISSNコード：13484214/09169636
掲載区分	国外
巻・号・頁	49(3),pp.949-957
著者・共著者	Yoshinori Okazaki, Naohiro Komura, Shintaro Minegishi, Akira Horigome, Kyoko Hattori, Satoshi Ishii, Yohei Hanajima, Masanari Asai, Takumi Tokoro, Nobuyuki Horita, Tomoaki Ishigami, Kiyoshi Hibi, Yuichiro Yano, Akira Nishiyama, Koichi Node, Satoshi Morimoto (as Japanese Society of Hypertension (JSH) working group “Onco-Hypertension”)
発行年月	2026/03
概要	As cancer treatments improve, hypertension has become a frequent comorbidity among cancer survivors. While it may result from the cancer itself or its treatment, the impact of hypertension on cancer recurrence remains poorly understood. We conducted a systematic review and meta-analysis to evaluate the association between hypertension and the risk of recurrence of solid cancers in adult survivors. We searched four major databases including PubMed, Embase, Web of Science and the Cochrane Library for relevant studies involving adult cancer survivors who had completed initial treatment for solid tumors. The primary outcome was recurrence risk in hypertensive versus normotensive individuals, assessed using hazard ratios (HRs) pooled through a random-effects model. Heterogeneity across studies was assessed using the I² statistic. Of 1337 records screened, 13 observational studies including 15 cohorts comprising 50,549 participants met the inclusion criteria. In the overall analysis, hypertension was not significantly associated with an increased risk of solid tumor recurrence (HR: 1.09; 95% CI: 0.97-1.22; I² = 49%). Subgroup analyses showed a significant association in colorectal cancer (HR: 1.18; 95% CI: 1.02-1.36; I² = 27%), but not in breast (HR: 1.09; 95% CI: 0.86-1.40; I² = 40%) or prostate cancer (HR: 1.12; 95% CI: 0.91-1.38; I² = 53%). However, no significant difference was found across subgroups (P = 0.18). These findings suggest a potential link between hypertension and recurrence in specific cancers, particularly colorectal cancer. Comprehensive blood pressure control may play a key role in the long-term management of cancer survivors.
DOI	10.1038/s41440-025-02431-5
PMID	41203853