ホシノ　ジュンイチ   Hoshino Junichi   星野　純一    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Ectopic parathyroid hormone-producing cervical cancer requiring hemodialysis owing to acute hypercalcemia: a case report
掲載誌名	正式名：Renal Replacement Therapy ISSNコード：20591381
掲載区分	国外
出版社	BioMed Central
巻・号・頁	11,pp.s41100-025-00679-8
著者・共著者	Ushio Yusuke, Iwatani Yosuke, Suyama Mayuko, Tanaka Ayano, Mizutani Mihoko, Seki Momoko, Shimizu Yuka, Shiogai Koichiro, Ando Nagisa, Sato Nozomi, Higashi Kouta, Tazawa Masahide, Nomura Kana, Kato Haruka, Nakai Anna, Sumori Hitoko, Makabe Shiho, Kobayashi Shizuka, Kawaguchi Yuki, Manabe Shun, Kataoka Hiroshi, Ito Naoko, Taneda Sekiko, Yamamoto Tomoko, Nitta Kosaku, Hoshino Junichi
担当区分	最終著者
発行年月	2025/10/13
概要	Background Parathyroid hormone-related protein (PTHrP) is often the underlying cause of malignancies complicated by hypercalcemia. However, in rare instances, ectopic production of parathyroid hormone (PTH) by tumors can be responsible, with hypercalcemia rarely reported. Case presentation We report the case of a 55-year-old female who was admitted with general fatigue and developed acute consciousness disturbance with a rapid rise in intact serum PTH to 12,258 pg/mL and corrected calcium to 14.3 mg/dL. Despite zoledronic acid administration, hypercalcemia remained refractory and required hemodialysis. Calcium levels and consciousness improved; however, her overall condition deteriorated, and she eventually succumbed to progressive hepatic failure. Postmortem examination revealed multiple metastases from ectopic PTH-producing cervical cancer. Conclusions Although ectopic PTH-producing malignancies are extremely rare, ectopic PTH-producing tumors should be considered when unexplained hypercalcemia with negative PTHrP is encountered. Prompt initiation of hemodialysis is warranted in patients with severe symptomatic hypercalcemia.
DOI	https://doi.org/10.1186/s41100-025-00679-8
文献番号	ZB07390005<Pre 医中誌>