|
クボタ ショウコ
KUBOTA Shouko
久保田 晶子 所属 医学部 医学科（附属足立医療センター） 職種 助教 |
|
| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Prognostic value of the international association for the study of lung cancer grading system and its association with the tumor microenvironment in stage I EGFR-muted lung adenocarcinoma. |
| 掲載誌名 | 正式名：European journal of cancer (Oxford, England : 1990) 略 称：Eur J Cancer ISSNコード：18790852/09598049 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 207,pp.114184 |
| 著者・共著者 | Shoko Kubota†, Tetsuro Taki*, Tomohiro Miyoshi, Kenta Tane, Joji Samejima, Keiju Aokage, Masashi Wakabayashi, Kotaro Nomura, Michiko Nagamine, Motohiro Kojima, Shingo Sakashita, Naoya Sakamoto, Masahiro Tsuboi, Genichiro Ishii |
| 担当区分 | 筆頭著者 |
| 発行年月 | 2024/08 |
| 概要 | INTRODUCTION:The International Association for the Study of Lung Cancer (IASLC) grading system predicts early lung adenocarcinoma outcomes.METHODS:The purpose of this study is to examine prognostic value of the IASLC grading system and its association with the tumor microenvironment (TME) in Stage I EGFR-muted lung adenocarcinoma. Based on the IASLC grading system, we compared the clinicopathological characteristics of EGFR-mutated lung adenocarcinoma (n = 296). In addition, we examined the expression level of E-cadherin in tumor cells and counted the number of tumor-infiltrating lymphocytes (TILs; CD8, CD20, CD138, and Foxp3), tumor-associated macrophages (TAMs; CD204), and cancer-associated fibroblasts (CAFs; podoplanin) using semi-automatic digital pathology image analysis.RESULTS:Recurrence-free survival (RFS) curve showed that survival of grade 3 was significantly shorter than that of grade 1 (P < 0.01) and grade 2 (P = 0.03). Multivariate analysis of RFS revealed the invasive size, lymphatic permeation, and grade 3 (P < 0.01) as independent poor prognostic factors. The number of CD204 +TAMs and PDPN+CAFs was significantly higher in grade 3 than in grade 1 or 2 (all P < 0.01). Among the intermediate grade by the predominant subtype based classification, cases classified as grade 3 by the new classification had higher number of CD204 +TAMs (P < 0.01) and PDPN+CAFs (P = 0.02) than those classified as grade 2.CONCLUSION:The IASLC grading system correlated with the outcomes of EGFR-mutated lung adenocarcinoma. Grade 3 was found to have the TME that most contributes to tumor progression, which probably explained their poor prognosis. |
| DOI | 10.1016/j.ejca.2024.114184 |
| PMID | 38936102 |