タバタ　ツトム   TABATA Tsutomu   田畑　務    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	症例報告
言語種別	英語
査読の有無	査読なし
表題	High-grade gliomas derived from an ovarian mature teratoma: clonal dynamics and genetic insights.
掲載誌名	正式名：International cancer conference journal 略　 称：Int Cancer Conf J ISSNコード：21923183/21923183
掲載区分	国外
巻・号・頁	14(4),pp.421-427
著者・共著者	Kota Yamauchi, Junzo Hamanishi, Koichi Watanabe, Nobuyuki Kakiuchi, Yasuhide Takeuchi, Hiroyuki Katsuragawa, Koji Yamanoi, Takashi Motohashi, Yuko Hosoe, Ken Yamaguchi, Kiyoshi Yamaguchi, Seiya Imoto, Tsutomu Tabata, Yoichi Furukawa, Yohei Mineharu, Yoshiki Arakawa, Seishi Ogawa, Sachiko Minamiguchi, Masaki Mandai
担当区分	責任著者
発行年月	2025/10
概要	UNLABELLED:High-grade glioma (HGG) arising from a mature ovarian teratoma is extremely rare and its genetic alterations remain largely unknown. We report a case of WHO Grade 4 HGG (HGG-G4) developing 3 years after cystectomy for ovarian mature teratoma, where a WHO Grade 3 HGG (HGG-G3) was identified upon pathological reevaluation. Whole-exome sequencing confirmed the clonal relationship between HGG-G3 and HGG-G4, revealing genome-wide copy-neutral loss of heterozygosity, copy-number alterations, and whole-genome doubling in both HGGs. Genomic and epigenetic analyses have suggested multistep tumorigenesis and clonal alteration during the clinical course, particularly in response to chemotherapy, in HGGs arising from ovarian teratomas.SUPPLEMENTARY INFORMATION:The online version contains supplementary material available at 10.1007/s13691-025-00790-x.
DOI	10.1007/s13691-025-00790-x
PMID	41395561