オカザキ　ケン   OKAZAKI Ken   岡崎　賢    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Clinical outcomes of twice-weekly teriparatide acetate administration in osteoporosis.
掲載誌名	正式名：Archives of osteoporosis 略　 称：Arch Osteoporos ISSNコード：18623514
掲載区分	国外
巻・号・頁	20(1),pp.144
著者・共著者	Ayako Tominaga, Hideyuki Maruki, Keiji Wada, Yasushi Terayama, Hideharu Nishi, Yoshiharu Kato, Ken Okazaki
担当区分	最終著者
発行年月	2025/11
概要	UNLABELLED:W2TPD, a twice-weekly teriparatide administration regimen, was used on 163 patients. The continuation rate was 47%, with only one new fracture. Even after performing antiresorptive therapy, spine BMD increased significantly in the majority of groups. W2TPD demonstrated good efficacy and tolerability in a real-world sequential osteoporosis treatment model.PURPOSE:Teriparatide is the most commonly administered daily, but there are also once-weekly and twice-weekly regimens. The former demonstrated high efficacy in increasing bone mineral density (BMD) and preventing new fractures; however, the continuation rate was reported to be low due to a high incidence of side effects. As a result, the twice-weekly teriparatide administration schedule (W2TPD) was created. In this study, we conducted a real-world clinical evaluation of its efficacy as part of a sequential osteoporosis treatment regimen.METHODS:The study included 163 patients with osteoporosis who were treated with W2TPD. Patients treated with W2TPD were divided into five groups based on their prior medication use: treatment-naïve (N), post-denosumab (post-D), post-bisphosphonate (post-B), post-romosozumab (post-R), and post-SERM (post-S). We examined treatment continuation rates, adverse events, and changes in BMD.RESULTS:The overall treatment continuation rate was 47.9%, with only one patient developing a new fracture during treatment. Gastrointestinal side effects, such as heartburn, nausea, and vomiting, were common. The percent changes in spine BMD were 10%, 5.2%, 5%, - 1.5%, and 12.3% in the N, post-D, post-B, post-R, and post-S groups, respectively. Meanwhile, hips were found in 3.1%, 0.4%, 1.5%, 0%, and 2.2%, respectively. In terms of spine BMD, all groups except post-R had responder rates greater than 50%.CONCLUSION:The continuation rate of W2TPD was 47% and resulted in particularly favorable BMD gains in the spine. It was also discovered to be effective in increasing BMD even when following bisphosphonate treatment.
DOI	10.1007/s11657-025-01622-4
PMID	41258613