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ワサ マサノリ
WASA Masanori
和佐 正紀 所属 医学部 医学科（附属足立医療センター） 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Surfactant therapy using a bronchofiberscope in respiratory distress syndrome. |
| 掲載誌名 | 正式名：Pediatrics international : official journal of the Japan Pediatric Society 略 称：Pediatr Int ISSNコード：1442200X/13288067 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 65(1),pp.e15478 |
| 著者・共著者 | Masanori Wasa, Hisaya Hasegawa, Hirotaka Kihara, Yosuke Yamada, Masae Mizogami, Rei Kitamura, Kenta Ikeda |
| 担当区分 | 筆頭著者,責任著者 |
| 発行年月 | 2023/01 |
| 概要 | BACKGROUND:Avoiding endotracheal intubation and using nasal continuous positive airway pressure as the initial treatment is recommended in infants with respiratory distress syndrome (RDS), and modes of lesser invasive surfactant administration have recently been reported. We report a pilot study assessing the feasibility of surfactant therapy using a bronchofiberscope (STUB) in RDS.METHODS:Surfactant was administered to 31 preterm infants (gestational age range of 28 weeks 0 days to 36 weeks 6 days) diagnosed with RDS, through the working channel of the bronchofiberscope or endotracheal tubes. Patient characteristics, outcomes, adverse events, and comorbidities were assessed in the two groups.RESULTS:Twelve infants received STUB. Two of the 12 infants (17%) needed subsequent intubation and additional surfactant administration. Nineteen infants received surfactant through endotracheal tubes. Four of the 19 infants (21%) required additional surfactants. There was no significant difference in the number of infants that needed additional surfactant (p = 1.00). Gestational age, birthweight, length of hospitalization, adverse events, such as desaturations and bradycardias, and comorbidities were similar between the two groups. Days of invasive ventilation were significantly shorter in the STUB group (p = 0.0002).CONCLUSION:STUB was feasible in this small cohort and reduced the need for intubation to 17%, leading to fewer days of invasive ventilation, without increasing comorbidities and adverse events. To the best of our knowledge, this is the first study to administer surfactants using bronchofiberscopes. |
| DOI | 10.1111/ped.15478 |
| PMID | 36656737 |