ハシモト　ヒロツグ   HASHIMOTO Hirotsugu   橋本　浩次    所属   医学部 医学科    職種   准教授
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Pancreatic Amphicrine Carcinoma With Acinar and Neuroendocrine Differentiation: A Comprehensive Case With Radiological, Cytopathological and Ultrastructural Findings, and Literature Review.
掲載誌名	正式名：Pathology international 略　 称：Pathol Int ISSNコード：14401827/13205463
掲載区分	国外
巻・号・頁	76(2),pp.e70094
著者・共著者	Hirotsugu Hashimoto†*, Hajime Horiuchi, Shouichi Satou, Yuji Fujita, Masashi Kusakabe, Teppei Morikawa
担当区分	筆頭著者,責任著者
発行年月	2026/02
概要	Amphicrine carcinoma is a rare malignancy exhibiting dual differentiation toward both exocrine and endocrine lineages within the same tumor cells. We report a case of pancreatic amphicrine carcinoma with acinar and neuroendocrine differentiation in an elderly man (85 years old at surgery). An 8-mm nodule in the pancreatic body was detected by abdominal ultrasonography. Magnetic resonance imaging revealed a high-signal nodule on diffusion-weighted imaging but indistinct findings on T1- and T2-weighted images, and the lesion was also indistinct on dynamic contrast-enhanced computed tomography. Endoscopic ultrasonography (EUS) clearly visualized the lesion, and EUS-guided fine-needle aspiration revealed malignant cells with acinar-like structures and granular cytoplasm. Distal pancreatectomy was subsequently performed, and the tumor was pathologically diagnosed as amphicrine carcinoma. Dual differentiation toward acinar and neuroendocrine lineages was confirmed by immunohistochemistry and ultrastructural examination. To our knowledge, this is the first report to comprehensively describe a pancreatic acinar-type amphicrine carcinoma, including radiological, cytopathological, and ultrastructural findings. The present case highlights the diagnostic value of multimodal imaging and cytopathological evaluation and may serve as a reference for diagnosing such rare tumors. It may also offer new insights into the future classification of pancreatic amphicrine and amphicrine-like tumors within a similar biological spectrum.
DOI	10.1111/pin.70094
PMID	41693297