オカダ　トモコ   OKADA Tomoko   岡田　朋子    所属   医学部 医学科（附属八千代医療センター）    職種   助教
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	A Case of Severe Neonatal COVID-19 Pneumonia Requiring Prolonged Mechanical Ventilation Without Long-Term Respiratory Sequelae.
掲載誌名	正式名：Cureus 略　 称：Cureus ISSNコード：21688184/21688184
掲載区分	国外
巻・号・頁	17(12),pp.e99444
著者・共著者	Tomoko Okada, Sho Kimura, Takafumi Honda, Kumi Yasukawa, Jun-Ichi Takanashi
担当区分	筆頭著者
発行年月	2025/12
概要	Numerous reports have described severe effects of novel coronavirus (SARS-CoV-2) in adults, often accompanied by long-term respiratory sequelae, such as pulmonary fibrosis. By stark contrast, most pediatric cases of respiratory illness associated with SARS-CoV-2 are mild: severe pneumonia caused by SARS-CoV-2 infection is rare in children. Nevertheless, data reflecting long-term respiratory outcomes in this population are scarce. This report describes prolonged mechanical ventilation for managing a case of severe neonatal pneumonia caused by SARS-CoV-2. The patient, a full-term neonate who developed fever at two days of age, was subsequently diagnosed with moderate acute respiratory distress syndrome (ARDS) secondary to COVID-19. Mechanical ventilation was administered for three weeks. Following extubation, the patient's respiratory condition improved steadily. He was discharged without apparent sequelae. At two-year follow-up, he had no respiratory or other systemic sequelae. To monitor for potential long-term pulmonary damage, we performed serial chest computed tomography (CT) scans and measured serum KL-6 levels. The latter were elevated during the acute phase (2,600 U/mL) but decreased to 450 U/mL within three months. CT imaging initially showed ground-glass opacities, which resolved over time. This case highlights the possibility of full recovery without long-term respiratory complications, even in neonates with severe SARS-CoV-2 pneumonia requiring prolonged ventilatory support. This report is among the very few documenting long-term follow-up in this patient population.
DOI	10.7759/cureus.99444
PMID	41552077