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ワカバヤシ ヒデタカ
WAKABAYASHI Hidetaka
若林 秀隆 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Association of antipsychotic drugs and tongue strength in patients with dysphagia: A cross-sectional study. |
| 掲載誌名 | 正式名：Geriatric nursing (New York, N.Y.) 略 称：Geriatr Nurs ISSNコード：15283984/01974572 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 64,pp.103334 |
| 著者・共著者 | Hiroki Maki, Akio Shimizu, Hidetaka Wakabayashi, Shinta Nishioka, Ryo Momosaki |
| 発行年月 | 2025 |
| 概要 | BACKGROUND:Antipsychotic drugs negatively affect muscle strength. Previous studies have shown an association between handgrip strength and tongue strength. Therefore, antipsychotic drugs may be related to tongue strength, a surrogate marker of swallowing function.OBJECTIVE:To investigate the association between antipsychotic drug use and tongue strength in patients with dysphagia.METHODS:This multicenter cross-sectional study included patients with dysphagia. Tongue strength was assessed at each facility using the JMS tongue pressure measuring instrument. Antipsychotic drugs assessed included aripiprazole, quetiapine, risperidone, and brexpiprazole. A multivariate model was used to analyze the association between the use of antipsychotic drugs and tongue strength.RESULTS:In total, 126 patients (mean age 80.7 ± 11.1 years, 49.2 % female) were included, and 12 (9.5 %) patients had used antipsychotic drugs. Their tongue strength tended to be lower compared to those with no antipsychotic drug use (11.9 [0.3-22.2] kPa vs. 16.3 [10.1-24.4] kPa, P = 0.066). The multivariate linear regression analysis showed that antipsychotic drug use was negatively associated with tongue strength (β -6.681, 95 % confidence interval [-12.535, -0.828], P = 0.026). However, the binomial logistic regression analysis revealed no association between antipsychotic drug use and low tongue pressure (odds ratio = 2.561, 95 % confidence interval [0.598, 10.972], P = 0.205).CONCLUSIONS:The use of antipsychotic drugs was negatively associated with tongue strength. The reduction or discontinuation of antipsychotic drugs should be carefully considered in patients with dysphagia. |
| DOI | 10.1016/j.gerinurse.2025.04.007 |
| PMID | 40383674 |