ワカバヤシ　ヒデタカ   WAKABAYASHI Hidetaka   若林　秀隆    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Cachexia risk classification using the Asian Working Group for cachexia criteria in patients with dysphagia: A retrospective cohort study.
掲載誌名	正式名：Clinical nutrition ESPEN 略　 称：Clin Nutr ESPEN ISSNコード：24054577/24054577
掲載区分	国外
巻・号・頁	70,pp.1
著者・共著者	Shingo Kakehi, Hidetaka Wakabayashi, Takako Nagai, Eri Isono, Junki Ninomiya, Yukiko Otsuka, Shinta Nishioka, Ryo Momosaki
担当区分	2nd著者,責任著者
発行年月	2025/12
概要	BACKGROUND & AIMS:Although diagnostic criteria for cachexia exist, few risk classification systems are applicable in clinical practice. This study aimed to evaluate the clinical relevance of a novel cachexia risk classification based on the Asian Working Group for Cachexia (AWGC) criteria in patients with dysphagia.METHODS:This retrospective cohort study included 431 adult patients with dysphagia from a multicenter Japanese database. Sarcopenia and malnutrition were diagnosed using the AWGS 2019 and GLIM criteria, respectively. Patients were categorized into four original risk groups developed for this study based on AWGC criteria: No Risk (n = 255), Low Risk (n = 4), At Risk (n = 44), and Cachexia (n = 128). Low Risk group was excluded from analysis due to its small sample size. Mortality and functional outcomes were compared across the remaining three groups. Multinomial logistic regression was performed to identify factors independently associated with mortality.RESULTS:Mortality was significantly higher in Cachexia group (15.6 %) compared to At Risk (2.2 %) and No Risk (1.9 %) groups (P < 0.01). BI and FILS did not differ significantly among groups. BMI and calf circumference declined with increasing cachexia risk. Malnutrition and sarcopenia were most prevalent in Cachexia group. Cachexia classification was independently associated with mortality (OR: 7.98, 95 % CI: 3.08-24.7, P < 0.01), and women were also associated with higher mortality risk (OR: 2.57, 95 % CI: 1.04-6.91, P = 0.03).CONCLUSIONS:Novel AWGC criteria for cachexia risk classification were significantly associated with mortality, malnutrition, and sarcopenia in patients with dysphagia.
DOI	10.1016/j.clnesp.2025.09.007
PMID	40935187