オガワ　シンペイ   OGAWA Shinpei   小川　真平    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Analysis of clinicopathological features and oncological outcomes of ulcerative colitis-associated colorectal cancer based on macroscopic classification.
掲載誌名	正式名：International journal of colorectal disease 略　 称：Int J Colorectal Dis ISSNコード：14321262/01791958
掲載区分	国外
巻・号・頁	40(1),pp.223
著者・共著者	SAITO Ayano,YOKOYAMA Yuichiro,UCHINO Motoi,IKEUCHI Hiroki,OKABAYASHI Koji,OKA Shiro,HIGASHI Daijiro,OGAWA Shimpei,WATANABE Kazuhiro,SHIBUTANI Masatsune,OKITA Yoshiki,WAKAI Toshifumi,MIZUUCHI Yusuke,OKAMOTO Kinya,YAMADA Kazutaka,SATO Yu,OGINO Takayuki,KIMURA Hideaki,TAKAHASHI Kenichi,HIDA Koya,KINUGASA Yusuke,ISHIDA Fumio,OKUDA Junji,DAITO Koji,YAMAMOTO Takayuki,YAMAMOTO Seiichiro,KOYAMA Fumikazu,HANAI Tsunekazu,KOMORI Koji,SHIDA Dai,ARAKAKI Junya,FUJITA Fumihiko,YAMAGUCHI Shigeki,UENO Hideki,MATSUDA Keiji,MAEMOTO AtsuoNEZU, Riichiro,SASAKI Shin,SUNAMI Eiji,NOGUCHI Tatsuki,SUGIHARA Kenichi,AJIOKA Yoichi,ISHIHARA Soichiro
発行年月	2025/10
概要	PURPOSE:Few studies have reported the association of macroscopic classification with clinicopathological characteristics and prognosis of ulcerative colitis-associated colorectal cancer (UC-CRC), unlike sporadic CRC. In this study, we aimed to clarify the clinical significance of macroscopic classification of UC-CRC.METHODS:The cohort included 480 patients with UC-CRC with invasion beyond the muscularis propria treated at 43 Japanese institutions between 1983 and 2023. The patients were divided into six groups based on the macroscopic type (types 0-5), and clinicopathological features and prognoses were compared.RESULTS:Among 480 patients, 66 (13.8%), 75 (15.6%), 116 (24.2%), 63 (13.1%), 68 (14.2%), and 92 (19.2%) had type 0-5 tumors, respectively. There were significant differences in the clinicopathological characteristics with a younger age in type 4 or 5 tumors than in type 2 tumors (p < 0.01) and a higher frequency of undifferentiated carcinomas (p < 0.01) and lymph node metastasis (p < 0.01) and more advanced depth of invasion (p < 0.01) in type 4 tumors than in type 1 or 2 tumors. Type 4 and 5 were independent risk factors for 5-year recurrence-free survival (p = 0.02; type 4 [HR: 6.35], type 5 [HR: 5.25]) and type 0, 4, and 5 for overall survival (p = 0.02; type 0 [HR: 4.51], type 4 [HR: 5.70], type 5 [HR: 4.02]).CONCLUSIONS:Type 0, 4, and 5 tumors were characteristic macroscopic types of UC-CRC and correlated with worse prognosis. Therefore, endoscopic diagnosis of the macroscopic type of UC-CRC might be helpful in determining tumor aggressiveness.
DOI	10.1007/s00384-025-05001-w
PMID	41152600