ヤマグチ　シゲキ   YAMAGUCHI Shigeki   山口　茂樹    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Longitudinal follow-up of sexual function after surgery for ultra-low rectal cancers located within 5 cm of the anal verge: A multicentre collaborative study
掲載誌名	正式名：Colorectal disease 略　 称：Colorectal Dis ISSNコード：14631318/14628910
掲載区分	国外
巻・号・頁	27(4),pp.e70092
著者・共著者	ISHIYAMA Yasuhiro,HIRANO Yasumitsu,TSUKADA YuichiroWATANABE, Jun,FUKUNAGA Yosuke,SAKAMOTO Kazuhiro,HAMAMOTO Hiroki,YOSHIMITSU Masanori,HORIE Hisanaga,MATSUHASHI Nobuhisa,KURIU Yoshiaki,NAGAI Shuntaro,HAMADA Madoka,YOSHIOKA Shinichi,OHNUMA Shinobu,HAYAMA Tamuro,OTSUKA Koki,INOUE Yusuke,UEDA Kazuki,TOIYAMA Yuji,MARUYAMA Satoshi,YAMAGUCHI Shigeki,TANAKA Keitaro,NAITOH Takeshi,WATANABE Masahiko,SUZUKI Motoko,MISUSI Toshihiro,ITO Masaaki Ito,
発行年月	2025/04
概要	AIM:The effect of laparoscopic surgery on sexual function in patients with ultra-low rectal cancer remains unexplored. This multicentre study evaluated postoperative sexual function in male patients with rectal cancer located within 5 cm of the anal verge.METHOD:A total of 139 male patients aged ≤70 years with clinical T1-2N0M0 rectal cancer underwent laparoscopic surgery between January 2014 and March 2017 at 47 institutions. Sexual function was assessed using the International Index of Erectile Function (IIEF-15) and an ejaculation questionnaire preoperatively and at 3, 6, and 12 months postoperatively. Univariate and multivariate analyses were performed to examine risk factors for sexual dysfunction.RESULTS:The IIEF-15 scores showed a significant decrease at 3 months postoperatively, with partial recovery observed at 12 months; however, the scores remained below baseline levels. Age ≥ 56 years was identified as a significant risk factor for postoperative erectile dysfunction. Although ejaculatory function exhibited some improvement over 12 months, it did not return to preoperative levels. However, the orgasmic function, sexual desire, and overall satisfaction domains recovered close to their preoperative levels.CONCLUSION:Laparoscopic surgery for ultra-low rectal cancer significantly affects male sexual function, particularly in older patients. These findings highlight the necessity for thorough preoperative counselling and targeted postoperative management to address sexual dysfunction.
DOI	10.1111/codi.70092
PMID	40251144