|
ホシノ ジュンイチ
Hoshino Junichi
星野 純一 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
|
| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Efficacy of combined exercise and nutritional intervention for non-dialysis chronic kidney disease: A systematic review. |
| 掲載誌名 | 正式名：Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 略 称：J Ren Nutr ISSNコード：15328503/10512276 |
| 掲載区分 | 国外 |
| 巻・号・頁 | pp.online |
| 著者・共著者 | Tsuchida Yohei, Kabasawa Hideyuki, Uno Chiharu, Nishioka Shinta, Sofue Tadashi, Fujii Naohiko, Saitoh Masakazu, Narita Ichiei, Yamagata Kunihiro, Hoshino Junichi, Doi Etsuko, Hosojima Michihiro |
| 発行年月 | 2025/11/24 |
| 概要 | OBJECTIVE:This systematic review analyzed the efficacy of combined exercise and nutritional intervention for non-dialysis chronic kidney disease (CKD) patients in terms of survival rate, renal function, initiation rate of renal replacement therapy (RRT), muscle mass, physical function including peak volume of oxygen uptake (VO2 peak), and quality of life (QOL).
METHODS:Database searches were performed of PubMed and Web of Science for English-language articles and Ichu-shi web for Japanese-language articles up to 30 September 2024. Inclusion criteria were randomized controlled trials (RCTs) of adult patients with CKD (stages 3-5), excluding patients undergoing RRT and post-kidney transplant, in which the intervention group received combined exercise and nutritional intervention, and the control group received exercise intervention alone, nutritional intervention alone, or no intervention. Cochrane risk-of-bias tool for randomized trials ver. 2 and Cochrane Review Manager were used to assess the risk of bias in RCTs and meta-analyses, respectively. RESULTS:Five RCTs involving a total of 339 participants were analyzed. In our meta-analyses, the intervention was associated with a significant improvement in VO2 peak [mean difference = 2.70 ml/kg/min; 95% confidence interval: 1.22, 4.18], but no difference in renal function was observed. However, because the analyzed studies were limited in number and had substantial heterogeneity and risk of bias, the results of our meta-analysis should be regarded as a supplement to our systematic review. The outcomes, including survival rate, initiation rate of RRT, muscle mass, and QOL, were qualitatively summarized due to the small number of studies. CONCLUSION:More RCTs are needed in order to provide evidence-based validation of the efficacy of combined exercise and nutritional intervention for patients with non-dialysis CKD. |
| DOI | 10.1053/j.jrn.2025.10.018 |
| PMID | 41297686 |