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ホンダ ゴロウ
HONDA Gorou
本田 五郎 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Patients With Pancreatic Cancer With Synchronous Liver Oligometastasis Show a Significant Long-Term Survival Benefit From Resection Under Specific Conditions: A Multicenter National Cohort Study |
| 掲載誌名 | 正式名：Journal of hepato-biliary-pancreatic sciences 略 称：J Hepatobiliary Pancreat Sci ISSNコード：18686982/18686974 |
| 掲載区分 | 国内 |
| 巻・号・頁 | 32(8),pp.611-619 |
| 著者・共著者 | NAKATA Kohei,MIYASAKA Yoshihiro,ISHIZAWA Takeaki,OHTSUKA Masayuki,MIZUMA Masamichi,SATOI Sohei,HIDAKA Masaaki,SUZUKI Shuji,KURAHARA Hiroshi,KITAMI Chie,HIRANO Satoshi,Dongha Lee,KO Saiho,TAHARA Munenori,YOSHIOKA IsakuDATE, Kenjiro,NAGAI Kazuyuki,HONDA Goro,MIZUNO Shugo,HAKAMADA Kenichi,FURAGAWA Yasuro,MARUBASHI Shigeru,YOSHIAD HiroshiHORIGUCHI, Akihiko,HOSOUCHI Yasuo,IMAMURA Masafumi,GOTOHDA Naoto,NAGANO HiroakiTANI, Masaji,SUDO Takeshi,HIRASHITA Teijiro,ARITA Junichi,MURASE Katsutoshi,FUKUMITSU Ken,RIKIYAMA Toshiki,USUDA Teruyuki,ABE Toshiya,NAKAMURA Masafumi,ENDO Itaru |
| 発行年月 | 2025/08 |
| 概要 | BACKGROUND:In this study, we investigated the criteria that predict the long-term survival benefits after surgical resection in patients with pancreatic cancer accompanied by liver oligometastasis.METHODS:In total, 60 patients from 34 high-volume Japanese centers who underwent surgical resection for liver oligometastasis between 2005 and 2020 were included. Univariate and multivariate methods of survival analyses were performed. All patients were followed up for at least 36 months.RESULTS:Overall survival (OS) was significantly longer in the preoperative chemotherapy group than in the up-front surgery group (37.4 vs. 20.4 months, p = 0.001). In the operation with preoperative chemotherapy group, a complete response was observed in eight patients (28.6%). The 1-, 3-, and 5-year OS rates were 92.9%, 50.0%, and 35.7%, respectively. The multivariate analysis showed that low CA19-9 (< 100 U/mL; HR: 0.25; 95% CI: 0.06-0.96; p = 0.043), low CEA (< 5 U/mL; HR: 0.14; 95% CI: 0.04-0.48; p = 0.002), and resectable (R) or borderline resectable pancreatic cancer invading the portal vein (BR-PV) status (HR: 0.19; 95% CI: 0.07-0.51; p < 0.001) were positive prognostic factors. The median OS of the patients who met all three criteria was 106.6 months.CONCLUSION:Preoperative chemotherapy is essential for the treatment of liver oligometastases. Despite the high recurrence rates, patients who met the specific criteria have a favorable prognosis with liver resection. |
| DOI | 10.1002/jhbp.12181 |
| PMID | 40653657 |