ヤマモト　アツシ   YAMAMOTO Atsushi   山本　篤志    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Myocardial injury in Duchenne muscular dystrophy: assessment via cardiac magnetic resonance intra-voxel incoherent motion
掲載誌名	正式名：Heart and Vessels 略　 称：Heart Vessel ISSNコード：09108327
掲載区分	国外
出版社	Springer
巻・号・頁	40(8),pp.in press
著者・共著者	YAMAMOTO Atsushi†, NAGAO Michinobu, ISHIGAKI Keiko, SHICHIJI Minobu, KIHARA Yuuki, SAKAI Akiko, MINAMI Yuuichirou, GOTOU Yasuhiro, YONEYAMA Masami, SAKAI Shiyuuji, YAMAGUCHI Jiyun'ichi
担当区分	筆頭著者
発行年月	2025/07/21
概要	Duchenne muscular dystrophy (DMD) is a progressive myopathy caused by a mutation in the dystrophin gene. Cardiac disease is currently the leading cause of death in patients with DMD; thus, early diagnosis and management of cardiomyopathy are essential. Intra-voxel incoherent motion (IVIM) analysis provides quantitative values from diffusion-weighted imaging (DWI) and may serve as a novel index for evaluating myocardial properties in DMD. We conducted IVIM analysis in patients with DMD and compared their results with those of healthy volunteers to confirm that IVIM analysis can detect myocardial damage more effectively than conventional imaging methods. Patients with DMD who underwent cardiac magnetic resonance IVIM were enrolled. D and F values were measured using DWI of the left ventricle. Six healthy volunteers served as the control group. Twelve male patients with DMD were enrolled (median age, 14 years). Creatinine kinase levels were elevated, brain natriuretic peptide values remained within the normal range, and troponin T levels were only mildly elevated. The D value in patients with DMD was significantly higher than that in healthy volunteers, indicating increased diffusion in the myocardium (2.59 vs. 1.85, p = 0.0057); however, the F value was comparable between the two groups (0.62 vs. 0.61, p = 0.60). The D and F values from IVIM analysis provided a more detailed reflection of myocardial properties. Myocardial diffusion in patients with DMD was elevated compared with that in healthy volunteers.
DOI	10.1007/s00380-025-02580-0
PMID	40685477