サイトウ　サトシ   SAITOU Satoshi   斉藤　聡志    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Prospective assessment of depression and suicidality in patients with epilepsy having baseline NDDI-E Scores > 13: Associations with seizure frequency and psychiatric treatment.
掲載誌名	正式名：Epilepsy & behavior reports 略　 称：Epilepsy Behav Rep ISSNコード：25899864/25899864
掲載区分	国外
巻・号・頁	31,pp.100810
著者・共著者	Satoshi Saito, Go Taniguchi, Hideo Kato, Chihiro Nakata, Izumi Kuramochi
担当区分	筆頭著者
発行年月	2025/09
概要	The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) is commonly used to screen for major depressive disorder (MDD) in patients with epilepsy, yet little is known about longitudinal changes in NDDI-E scores in relation to seizure control and psychiatric care. This study evaluated temporal changes in NDDI-E total and Item 4 scores (ΔNDDI-E, ΔItem 4) over ≥6 months in 34 adults (≥18 years) with baseline NDDI-E scores >13. Patients were seen in a specialized outpatient psychiatry clinic within an epilepsy center. Data included Clinical Global Impression-Improvement (CGI-I) ratings by psychiatrists specialized in epilepsy care, seizure frequency, DSM-5-based psychiatric diagnoses, and treatment interventions (e.g., medication adjustments, psychotherapy, and psychosocial support). Patients also completed a self-report questionnaire. No significant difference in MDD diagnoses was found between those with baseline NDDI-E scores of 14-16 and ≥17 (6.7 % vs. 21.1 %, p = 0.36). Comorbidities included autism spectrum disorder, dissociative disorder, and other mental health conditions. Changes in seizure frequency did not correlate with ΔNDDI-E or CGI-I scores, while ΔNDDI-E and ΔItem 4 showed moderate correlations with CGI-I (ρ = 0.51 and 0.56). All patients with improved Item 4 scores had better CGI-I ratings (p < 0.001). Qualitative analysis indicated that emotional fluctuations and psychosocial stressors influenced NDDI-E scores. These results suggest that longitudinal improvement in NDDI-E Item 4 may serve as a marker for psychiatric benefit. Effective use of the NDDI-E requires considering the psychiatric and psychosocial dimensions beyond seizure control. To validate these findings, studies with larger sample sizes and longer follow-up are necessary.
DOI	10.1016/j.ebr.2025.100810
PMID	40786014