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イトウ マサフミ
ITOU Masafumi
伊藤 匡史 所属 医学部 医学科（東京女子医科大学病院） 職種 講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | A survey on the usage of decellularized tissues in orthopaedic clinical trials. |
| 掲載誌名 | 正式名：Bone & joint research 略 称：Bone Joint Res ISSNコード：20463758/20463758 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 12(3),pp.179-188 |
| 著者・共著者 | Masafumi Itoh, Junya Itou, Shinya Imai, Ken Okazaki, Kiyotaka Iwasaki |
| 発行年月 | 2023/03 |
| 概要 | Orthopaedic surgery requires grafts with sufficient mechanical strength. For this purpose, decellularized tissue is an available option that lacks the complications of autologous tissue. However, it is not widely used in orthopaedic surgeries. This study investigated clinical trials of the use of decellularized tissue grafts in orthopaedic surgery. Using the ClinicalTrials.gov (CTG) and the International Clinical Trials Registry Platform (ICTRP) databases, we comprehensively surveyed clinical trials of decellularized tissue use in orthopaedic surgeries registered before 1 September 2022. We evaluated the clinical results, tissue processing methods, and commercial availability of the identified products using academic literature databases and manufacturers' websites. We initially identified 4,402 clinical trials, 27 of which were eligible for inclusion and analysis, including nine shoulder surgery trials, eight knee surgery trials, two ankle surgery trials, two hand surgery trials, and six peripheral nerve graft trials. Nine of the trials were completed. We identified only one product that will be commercially available for use in knee surgery with significant mechanical load resistance. Peracetic acid and gamma irradiation were frequently used for sterilization. Despite the demand for decellularized tissue, few decellularized tissue products are currently commercially available, particularly for the knee joint. To be viable in orthopaedic surgery, decellularized tissue must exhibit biocompatibility and mechanical strength, and these requirements are challenging for the clinical application of decellularized tissue. However, the variety of available decellularized products has recently increased. Therefore, decellularized grafts may become a promising option in orthopaedic surgery. |
| DOI | 10.1302/2046-3758.123.BJR-2022-0383.R1 |
| PMID | 37051813 |