オカザキ　ケン   OKAZAKI Ken   岡崎　賢    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Romosozumab for managing severe osteoporosis in patients undergoing kidney transplantation: a retrospective case series.
掲載誌名	正式名：JBMR plus 略　 称：JBMR Plus ISSNコード：24734039/24734039
掲載区分	国外
巻・号・頁	9(6),pp.ziaf049
著者・共著者	Ayako Tominaga, Keiji Wada, Yoshiharu Kato, Ken Okazaki
担当区分	最終著者
発行年月	2025/06
概要	Recipients of kidney grafts often develop severe osteoporosis. However, no consensus has emerged on the most appropriate medications for managing osteoporosis in these recipients. In this study, we investigated the efficacy of romosozumab as an additional treatment option for managing severe osteoporosis in kidney transplant recipients (KTRs). Our retrospective observational study included 12 such recipients who were treated with romosozumab for 12 mo-8 newly initiated on romosozumab and 4 treated with romosozumab after initial treatment with other agents. Endpoints were side effects, new fractures, blood tests, and changes in BMD. Pearson correlation coefficients were used to assess associations of the percent change in bone mineral density after 1 yr of treatment with age, dialysis duration, and time (yr) since transplantation. During treatment with romosozumab, the patients did not develop severe hypocalcemia or experience marked deterioration of kidney function at 1 yr post-treatment. Metabolic markers of bone formation and resorption were similar to those in the general population with osteoporosis. The average changes in BMD at the spine and total hip were 15.18% and 8.83%, respectively, indicating a favorable increase. Further, the change in spine BMD was inversely correlated with age and time since transplantation. Treatment of osteoporosis with romosozumab was observed to be safe for KTRs and had a favorable therapeutic effect on both spine and hip BMD.
DOI	10.1093/jbmrpl/ziaf049
PMID	40353207