ニシダ タカシ   NISHIDA Takashi
  西田 隆司
   所属   医学部 医学科
   職種   助教
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Immunization with autotransporter Vag8 prevents coughing induced by Bordetella pertussis infection in mice.
掲載誌名 正式名:Microbiology and immunology
略  称:Microbiol Immunol
ISSNコード:13480421/03855600
掲載区分国外
巻・号・頁 67(6),pp.314-317
著者・共著者 Koichiro Suzuki, Yukihiro Hiramatsu, Takashi Nishida, Yasuhiko Horiguchi
発行年月 2023/06
概要 Bordetella pertussis causes pertussis, which is characterized by paroxysmal coughing. This disease is generally prevented through vaccination; however, the number of pertussis cases is increasing worldwide despite high vaccination coverage. We previously reported that an autotransporter of B. pertussis, virulence-associated gene 8 (Vag8), causes coughing in combination with pertussis toxin and lipooligosaccharide. Here, we show that immunization with Vag8 protected mice from coughing after B. pertussis infection and enhanced the efficacy of a current pertussis vaccine containing pertussis toxoid against the cough. Our findings indicate that Vag8 could be a vaccine antigen to prevent pertussis cough.
DOI 10.1111/1348-0421.13066
PMID 36976834