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ニシダ タカシ
NISHIDA Takashi
西田 隆司 所属 医学部 医学科 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Immunization with autotransporter Vag8 prevents coughing induced by Bordetella pertussis infection in mice. |
| 掲載誌名 | 正式名：Microbiology and immunology 略 称：Microbiol Immunol ISSNコード：13480421/03855600 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 67(6),pp.314-317 |
| 著者・共著者 | Koichiro Suzuki, Yukihiro Hiramatsu, Takashi Nishida, Yasuhiko Horiguchi |
| 発行年月 | 2023/06 |
| 概要 | Bordetella pertussis causes pertussis, which is characterized by paroxysmal coughing. This disease is generally prevented through vaccination; however, the number of pertussis cases is increasing worldwide despite high vaccination coverage. We previously reported that an autotransporter of B. pertussis, virulence-associated gene 8 (Vag8), causes coughing in combination with pertussis toxin and lipooligosaccharide. Here, we show that immunization with Vag8 protected mice from coughing after B. pertussis infection and enhanced the efficacy of a current pertussis vaccine containing pertussis toxoid against the cough. Our findings indicate that Vag8 could be a vaccine antigen to prevent pertussis cough. |
| DOI | 10.1111/1348-0421.13066 |
| PMID | 36976834 |