|
ニシダ タカシ
NISHIDA Takashi
西田 隆司 所属 医学部 医学科 職種 助教 |
|
| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Protective role of heme oxygenase-1 in Listeria monocytogenes-induced abortion. |
| 掲載誌名 | 正式名：PloS one 略 称：PLoS One ISSNコード：19326203/19326203 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 6(9),pp.e25046 |
| 著者・共著者 | Masato Tachibana, Masanori Hashino, Takashi Nishida, Takashi Shimizu, Masahisa Watarai |
| 発行年月 | 2011 |
| 概要 | It is well-known fact that various pathogens, including bacteria, virus, and protozoa, induce abortion in humans and animals. However the mechanisms of infectious abortion are little known. In this study, we demonstrated that Listeria monocytogenes infection in trophoblast giant cells decreased heme oxygenase (HO)-1 and B-cell lymphoma-extra large (Bcl-XL) expression, and that their overexpression inhibited cell death induced by the infection. Furthermore, HO-1 and Bcl-XL expression levels were also decreased by L. monocytogenes in pregnant mice. Treatment with cobalt protoporphyrin, which is known to induce HO-1, inhibited infectious abortion. Taken together, our study indicates that L. monocytogenes infection decreases HO-1 and Bcl-XL expression and induces cell death in placenta, leading to infectious abortion. |
| DOI | 10.1371/journal.pone.0025046 |
| PMID | 21949846 |