モリ　シユウスケ   MORI Shiyuusuke   森　周介    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Histological complete response in advanced gastric cancer after 2 weeks of S-1 administration as neoadjuvant chemotherapy
掲載誌名	正式名：Gastric Cancer ISSNコード：14363291/14363305
掲載区分	国内
出版社	Springer
巻・号・頁	9(2),pp.136-139
総ページ数	4
著者・共著者	Shusuke Mori
発行年月	2006/05/01
概要	Single-agent or combined chemotherapy with the novel oral fluoropyrimidine anticancer drug, S-1 (TS-1), has been reported to be useful for the treatment of advanced gastric cancer. Here, we report a patient with advanced gastric cancer achieving a complete response (CR) after 2 weeks of administration of S-1 as neoadjuvant chemotherapy. A 78-year-old woman with epigastric pain was diagnosed as having advanced gastric cancer. S-1 was administered orally, at a dose of 50 mg twice a day every day for 2 weeks, followed by a 2-week drug-free period. No obvious adverse reactions occurred. Subsequently, the patient underwent distal partial gastrectomy with D2 lymph node dissection. Pathological examination indicated no remnant signet-ring cells in the excised specimen, no lymph node metastasis, and unnatural fibrosis in one of the No. 3 lymph nodes. The neoadjuvant chemotherapy induced a CR according to the Japanese classification of gastric carcinoma.
DOI	10.1007/s10120-005-0358-z