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フナツ タカユキ
FUNATSU Takayuki
船津 尭之 所属 医学部 医学科（東京女子医科大学病院） 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Outcomes of patients with acute ischemic stroke associated with large vessel occlusion admitted during regular and off-hours: a sub-analysis of the RESCUE-Japan Registry 2. |
| 掲載誌名 | 正式名：Journal of neurointerventional surgery 略 称：J Neurointerv Surg ISSNコード：17598486/17598478 |
| 掲載区分 | 国外 |
| 巻・号・頁 | pp.1-6 |
| 著者・共著者 | Takayuki Funatsu, Hirotoshi Imamura, Nobuyuki Ohara, Satoru Fujiwara, Kazutaka Uchida, Takeshi Morimoto, Hiroshi Yamagami, Nobuyuki Sakai, Shinichi Yoshimura |
| 担当区分 | 筆頭著者 |
| 発行年月 | 2025/05 |
| 概要 | BACKGROUND:Off-hour admissions can adversely affect clinical outcomes, though evidence in patients with acute ischemic stroke (AIS) associated with large vessel occlusion (LVO) remains limited. This study aimed to examine the impact of off-hour versus regular-hour admissions on outcomes in patients with AIS associated with LVO.METHODS:Data from the Recovery by Endovascular Salvage for Cerebral Ultra-Acute Embolism (RESCUE)-Japan Registry 2, a prospective multicenter registry of patients with AIS associated with LVO were used. Eligible patients were aged ≥20 years and admitted within 24 hours of stroke onset. Off-hour admissions were defined as those occurring between 17:00 and 09:00 on weekdays and at all times on holidays, reflecting typical periods of reduced healthcare staffing. The primary outcome was a modified Rankin Scale score of 0-2, assessed 90 days post-admission.RESULTS:Of the 2390 patients, 1794 (71.7%) and 676 (28.3%) were admitted during off-hours and regular hours, respectively. Intravenous recombinant tissue-type plasminogen activator was administered to 617 (36.0%) off-hour patients and 336 (49.7%) regular-hour patients (P<0.0001). Endovascular therapy was provided to 915 (53.4%) off-hour patients and 361 (53.4%) regular-hour patients (P=0.99). Favorable outcomes (mRS score 0-2) were observed in 604 (35.2%) off-hour patients and 272 (40.2%) regular-hour patients (P=0.02). Multivariate logistic regression analysis showed no significant difference in the primary outcome between groups (adjusted OR 1.07; 95% CI 0.84 to 1.35; P=0.56).CONCLUSION:These findings suggest that off-hour and regular-hour admissions have similar clinical outcomes in patients with AIS associated with LVO in this Japanese cohort. |
| DOI | 10.1136/jnis-2025-023127 |
| PMID | 40316320 |