ホシノ　ジユンイチ   HOSHINO Jiyun'ichi   星野　純一    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Trend of treatment strategy for amyloid light-chain amyloidosis: a-single center experience.
掲載誌名	正式名：Clinical and experimental nephrology 略　 称：Clin Exp Nephrol ISSNコード：14377799/13421751
掲載区分	国外
巻・号・頁	pp.online
著者・共著者	Yoshifumi Ubara, Kei Kono, Junichi Hoshino, Takehiko Wada, Atsushi Wake, Kenichi Ohashi, Naoki Sawa
発行年月	2025/05/15
概要	Before 2000, AL amyloidosis was considered an incurable disease. However, in the 2000s, autologous peripheral blood stem cell transplantation therapy using vincristine + doxorubicin + dexamethasone with high-dose melphalan (VAD + SCT) was initiated. Bone marrow cells are the site of AL amyloid production. By normalizing bone marrow cells, VAD + SCT not only reduces amyloid production but also improves renal tissue damaged by amyloid deposition. However, VAD + SCT was only applied to patients who met the criteria, such as being under 65 years of age and not affecting the heart. At our hospital, VAD + SCT was applied in 20 patients who met this criteria. After treatment, 5 died and 2 required hemodialysis, but the remaining 13 patients survived for more than 10 years, with resolution of proteinuria and maintenance of renal function. These outcomes indicate that suppression of amyloid production is an effective treatment for AL amyloidosis. In the 2020s, molecularly targeted drugs against the plasma cell CD38 began to be administered for the treatment of AL amyloidosis.
DOI	10.1007/s10157-025-02696-7
PMID	40372551