カタオカ　ヒロシ   KATAOKA Hiroshi   片岡　浩史    所属   医学部 医学科（東京女子医科大学病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Overexpression of plasmalemmal vesicle-associated protein-1 in patient with cyanotic nephropathy: a case report.
掲載誌名	正式名：BMC nephrology 略　 称：BMC Nephrol ISSNコード：14712369/14712369
掲載区分	国外
巻・号・頁	26(1),pp.109
著者・共著者	Ushio Yusuke, Hirata So, Manabe Shun, Suyama Mayuko, Tanaka Ayano, Seki Momoko, Kato Haruka, Nomura Kana, Nakai Anna, Sumori Hitoko, Kawaguchi Yuki, Kobayashi Shizuka, Makabe Shiho, Kataoka Hiroshi, Itoh Naoko, Taneda Sekiko, Honda Kazuho, Hoshino Junichi
発行年月	2025/03
概要	BACKGROUND:Cyanotic nephropathy (CN) is a known complication of cyanotic congenital heart disease (CCHD). However, many aspects of its pathophysiology remain unclear.CASE PRESENTATION:We report the case of a 29-year-old male with a history of tetralogy of Fallot. Renal biopsy revealed glomerular hypertrophy and focal segmental glomerulosclerosis. Electron microscopy revealed extensive endothelial cell damage. To investigate the etiology of endothelial cell damage, PAL-E staining was conducted, revealing staining along the glomerular capillary wall.CONCLUSION:This is the first report of PAL-E staining in CN, suggesting potential overexpression of PV-1. The association of PV-1 expression with endothelial cell damage indicates its role in the pathogenesis of CN.
DOI	10.1186/s12882-025-04046-x
PMID	40033218