カンオ　ケイコ   KAN'O Keiko   神尾　敬子    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	The Utility and Limitations of Universal Polymerase Chain Reaction Screening for SARS-CoV-2 During Hospital Admission.
掲載誌名	正式名：Cureus 略　 称：Cureus ISSNコード：21688184/21688184
掲載区分	国外
巻・号・頁	16(5),pp.e61470
著者・共著者	Naruhiko Ogo, Satoshi Ikegame, Taeko Hotta, Keiko Kan-O, Yasuto Yoneshima, Yoshimasa Shiraishi, Kazuya Tsubouchi, Kentaro Tanaka, Isamu Okamoto
発行年月	2024/05
概要	OBJECTIVE:Universal polymerase chain reaction (PCR) screening for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on hospital admission is an effective approach to preventing coronavirus disease 2019 (COVID-19) outbreaks in medical facilities. However, false-positive test results due to a recent infection are a concern. We investigated the usefulness and limitations of universal PCR screening for SARS-CoV-2 on hospital admission in a real-world setting.METHODS:We retrospectively analyzed 1320 attempted hospital admissions for 775 patients at the Department of Respiratory Medicine, Kyushu University Hospital, between January 1, 2022, and May 2, 2023.RESULTS:Thirty-nine out of 1201 PCR tests (3.2%) yielded a positive result, with 22 of these results being considered false positives on the basis of a recent infection. We found that 39% of cases showed a positive PCR result between 31 and 60 days after the onset of COVID-19, although the threshold cycle (Ct) for target 1 (ORF1ab gene) of the Cobas SARS-CoV-2 test (Roche Diagnostics, Basel, Switzerland) was >30 in most instances.CONCLUSION:Hospital admission based on the results of PCR screening for SARS-CoV-2 should take into account not only PCR positivity but also the Ct value and recent COVID-19 history.
DOI	10.7759/cureus.61470
PMID	38953084