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イカリ カツノリ
IKARI Katsunori
猪狩 勝則 所属 医学部 医学科（東京女子医科大学病院） 職種 教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Association between vertebral fractures and comorbidities in patients with rheumatoid arthritis: a cross-sectional study. |
| 掲載誌名 | 正式名：Journal of bone and mineral metabolism 略 称：J Bone Miner Metab ISSNコード：14355604/09148779 |
| 掲載区分 | 国外 |
| 巻・号・頁 | pp.Epub |
| 著者・共著者 | Mochizuki Takeshi, Yano Koichiro, Otani Naoko, Hiroshima Ryo, Ikari Katsunori, Okazaki Ken |
| 発行年月 | 2025/03 |
| 概要 | INTRODUCTION:Patients with rheumatoid arthritis (RA) are at an increased risk of osteoporosis and vertebral fractures. We investigated the risk factors for vertebral fractures and severe vertebral fractures in patients with RA, including comorbidities and urinary pentosidine levels.MATERIALS AND METHODS:This study included 637 patients with available clinical data on urinary pentosidine levels, vertebral fractures, and comorbidities. Vertebral fractures were evaluated using plain X-ray imaging. Comorbidities considered relevant to osteoporosis were type 2 diabetes mellitus, chronic kidney disease, and lung diseases.RESULTS:The prevalence of vertebral fractures in this cohort was 30.1%. Patients with vertebral fracture Patients with vertebral fractures were significantly more likely to be older [odds ratio (OR) 1.075; 95% confidence interval (CI) 1.049-1.1.03], had higher prevalence of comorbidities (OR 1.770; 95% CI 1.138-2.753), higher urinary pentosidine levels (OR 1.028; 95% CI 1.013-1.044), higher history of non-vertebral fractures (OR 2.084; 95% CI 1.222-3.557), and lower total hip T-score (OR 0.526; 95% CI 0.329-0.841) than patients without vertebral fractures. Among patients with vertebral fractures, 54.2% had severe vertebral fractures. Patients with severe vertebral fractures were more likely to have lower lumbar spine T-scores (OR 0.768; 95% CI 0.622-0.949) than patients with non-severe vertebral fractures.CONCLUSIONS:This study identified factors associated with vertebral fractures and severe vertebral fractures in patients with RA. Notably, vertebral fractures were associated with comorbidities and urinary pentosidine levels. In patients with RA and vertebral fractures, low BMD in the lumbar spine was a significant factor associated with severe vertebral fractures. |
| DOI | 10.1007/s00774-025-01597-9 |
| PMID | 40148713 |