イカリ　カツノリ   IKARI Katsunori   猪狩　勝則    所属   医学部 医学科（東京女子医科大学病院）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Imaging assessment of malignancy screening using computed tomography and diffusion-weighted whole-body imaging with background body signal suppression in rheumatoid arthritis.
掲載誌名	正式名：Modern rheumatology 略　 称：Mod Rheumatol ISSNコード：14397609/14397595
掲載区分	国外
巻・号・頁	pp.Epub
著者・共著者	Mochizuki Takeshi, Yano Koichiro, Ikari Katsunori, Otani Naoko, Hiroshima Ryo, Okazaki Ken
発行年月	2025/03
概要	OBJECTIVES:To investigate differences in information obtained from plain computed tomography (CT) and diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) during malignancy screening in patients with rheumatoid arthritis (RA).METHODS:We enrolled 524 patients with RA who underwent plain CT from the chest to the pelvis and DWIBS. CT and DWIBS were performed within three months of each other. Rheumatologists, radiologists, and pulmonologists interpreted the plain CT and DWIBS images.RESULTS:The prevalence of malignancy was 3.1%. Prostate, lung, breast, uterine, ovarian, and fallopian tube cancers were detected in 7, 4, 2, 1, 1, and 1 patient, respectively. The sensitivities of CT and DWIBS were 75.0% and 93.8%, respectively (P = 0.333). The specificities of CT and DWIBS were 76.0% and 85.8%, respectively (P < 0.001). The prevalence rates of interstitial lung disease, colonic diverticula, and kidney stones on CT were 17.6%, 27.1% and 19.1%, respectively. The prevalence of lymphadenopathy in patients who underwent DWIBS was 3.6%.CONCLUSION:This study suggests that DWIBS is superior to or equivalent to CT for malignancy screening. Our findings have important implications for imaging-based screening and can help address cancer-related issues in RA treatment.
DOI	10.1093/mr/roaf030
PMID	40119621