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ワカバヤシ ヒデタカ
WAKABAYASHI Hidetaka
若林 秀隆 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Gut microbiome diversity and nutrition intake in post-stroke patients. |
| 掲載誌名 | 正式名：Geriatrics & gerontology international 略 称：Geriatr Gerontol Int ISSNコード：14470594/14470594 |
| 掲載区分 | 国内 |
| 巻・号・頁 | 25(4),pp.535-542 |
| 著者・共著者 | Nagano Fumihiko, Yoshimura Yoshihiro, Wakabayashi Hidetaka, Matsumoto Ayaka, Shimazu Sayuri, Shiraishi Ai, Bise Takahiro, Kido Yoshifumi, Hamada Takenori, Kuzuhara Aomi, Yoneda Kouki, Maeda Keisuke |
| 発行年月 | 2025/04 |
| 概要 | AIM:This study aimed to investigate the association between energy intake and gut microbiome diversity in patients following stroke.METHODS:A cross-sectional study was conducted with 156 patients following stroke aged ≥65 years admitted to a rehabilitation hospital (mean age, 78 ± 7 years; 69 women). Energy intake was calculated from average food consumption during the first week after admission. Gut microbiome diversity was assessed using three indices derived from 16S rRNA sequencing of stool samples: the Shannon index, operational taxonomic unit (OTU) richness and Faith's phylogenetic diversity (PD). Sex-stratified multiple linear regression analysis evaluated the association between energy intake and gut microbiome diversity, adjusting for confounders such as age, body weight, inflammation markers, nutritional status, and medication.RESULTS:The study included 156 patients following stroke (mean age, 78 ± 7 years; 69 women). The median energy intake was 1600 (interquartile range [IQR], 1400-1800] kcal/day for all participants. The median for gut microbiome diversity indices were Shannon index, 6.3 (IQR, 5.9-6.5); OTU richness, 217.3 (IQR, 181.9-258.1); and Faith's PD, 22.4 (IQR, 19.3-27.2). In women, energy intake was significantly positively associated with the Shannon index (β = 0.233, P = 0.026), OTU richness (β = 0.228, P = 0.036), and Faith's PD (β = 0.212, P = 0.038). In men, energy intake was significantly positively associated with the Shannon index (β = 0.230, P = 0.027), OTU richness (β = 0.211, P = 0.040), and Faith's PD (β = 0.198, P = 0.043).CONCLUSIONS:Adequate energy intake may play an important role in preserving gut microbiome diversity in patients. Further longitudinal studies are needed to confirm these associations, clarify causality, and explore underlying mechanisms. Geriatr Gerontol Int 2025; 25: 535-542. |
| DOI | 10.1111/ggi.70017 |
| PMID | 40091684 |