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アカバ トモヒロ
AKABA Tomohiro
赤羽 朋博 所属 医学部 医学科（東京女子医科大学病院） 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Effectiveness of Oral Prophylactic Antibiotics for Diagnostic Bronchoscopy: A Nationwide Database Study. |
| 掲載誌名 | 正式名：Annals of the American Thoracic Society 略 称：Ann Am Thorac Soc ISSNコード：23256621/23256621 |
| 掲載区分 | 国外 |
| 巻・号・頁 | pp.Online |
| 著者・共著者 | Akaba Tomohiro†, Jo Taisuke, Suzuki Jun, Kimura Yuya, Matsui Hiroki, Fushimi Kiyohide, Tagaya Etsuko, Yasunaga Hideo |
| 担当区分 | 筆頭著者 |
| 発行年月 | 2025/01 |
| 概要 | RATIONALE:Although the guidelines generally omit routine antibiotic prophylaxis for diagnostic bronchoscopy, this recommendation is primarily based on studies with relatively small sample sizes conducted at single institutions. Moreover, the applicability of recent technical and procedural advancements to these guidelines remains uncertain.OBJECTIVES:To evaluate whether oral prophylactic antibiotic administration for diagnostic bronchoscopy reduces post-bronchoscopy infections among non-infectious diseases in the current setting.METHODS:Using the Diagnosis Procedure Combination database, a national inpatient database in Japan, we identified patients who underwent diagnostic bronchoscopy with or without oral prophylactic antibiotics between April, 2020 and March, 2022. We employed the propensity score-stabilized inverse probability of treatment weighting and instrumental variable analyses to compare post-bronchoscopy infections between the groups. Stratified analyses were also conducted based on patient profiles and antibiotic types.RESULTS:A total of 68,660 eligible patients were divided into prophylaxis (N=10,426) and no prophylaxis (N=58,234) groups. Post-bronchoscopy infections were observed in 612 patients (0.89%). The stabilized inverse probability of treatment weighting analysis showed that the prophylactic group was significantly associated with a decrease in post-bronchoscopy infections (odds ratio, 0.60; 95% confidence interval, 0.45 to 0.80). The instrumental variable analysis showed similar results (odds ratio, 0.50; 95% confidence interval, 0.34-0.74). Oral antibiotic prophylaxis was associated with reduction in post-bronchoscopy infection in patients who were older than 70 years, underwent bronchoscopy for malignancy, underwent biopsy or bronchoalveolar lavage, or received aminopenicillin or fluoroquinolone for prophylaxis.CONCLUSIONS:Our findings suggest a potential role for prophylactic antibiotics in reducing post-bronchoscopy infections among non-in |
| DOI | 10.1513/AnnalsATS.202407-796OC |
| PMID | 39847714 |