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マツモト エツコ
MATSUMOTO Etsuko
松本 悦子 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Predicting dupilumab effectiveness with Type-2 biomarkers: A real-world study of severe asthma. |
| 掲載誌名 | 正式名：Allergology international : official journal of the Japanese Society of Allergology 略 称：Allergol Int ISSNコード：14401592/13238930 |
| 掲載区分 | 国内 |
| 巻・号・頁 | 74(1),pp.144-155 |
| 著者・共著者 | Mizumura Kenji†, Gon Yasuhiro, Harada Norihiro, Yamada Shiho, Fukuda Asami, Ozoe Ryosuke, Maruoka Shuichiro, Abe Sumiko, Takahashi Kazuhisa, Tanaka Akihiko, Sagara Hironori, Akamatsu Taisuke, Shirai Toshihiro, Masaki Katsunori, Fukunaga Koichi, Kobayashi Konomi, Nagase Hiroyuki, Miyahara Nobuaki, Kanehiro Arihiko, Kitamura Noboru, Sugihara Naruhiko, Kumasawa Fumio, Terada-Hirashima Junko, Hojo Masayuki, Chibana Kazuyuki, Tagaya Etsuko |
| 発行年月 | 2025/01 |
| 概要 | BACKGROUND:The therapeutic effectiveness of dupilumab for severe asthma in real-world settings is yet to be prospectively investigated across multiple institutions, and uncertainties persist regarding predictive factors for its effectiveness. We aimed to assess the effectiveness of dupilumab and identify predictors of its effectiveness in real-world settings using two type-2 biomarkers: FeNO concentration and blood eosinophil count.METHODS:This prospective multicenter study included 103 patients with severe asthma. Exacerbations and respiratory functions were monitored for 24 weeks. Asthma control was evaluated using the Asthma Control Questionnaire-5. Clinical symptoms and their impact on cough and sputum were assessed using the Cough and Sputum Assessment Questionnaire (CASA-Q). Subgroup analyses of type-2 biomarkers were conducted based on FeNO levels and blood eosinophil counts at baseline.RESULTS:Treatment with dupilumab led to a reduction in exacerbations and enhancement in asthma control, FEV1, and CASA-Q scores. FEV1 improvement was correlated with enhancement in the sputum domain of the CASA-Q. Patients exhibiting elevated FeNO levels and blood eosinophil counts demonstrated more significant enhancements in FEV1. CASA-Q sputum domain scores were significantly higher in the group with elevated eosinophil counts. Regression analysis revealed that FeNO levels and blood eosinophil counts are significant predictors of FEV1 improvement, with blood eosinophil counts also predicting sputum improvement in patients treated with dupilumab.CONCLUSIONS:Type-2 biomarkers may act as indicators of improvement in FEV1 and sputum outcomes among patients with severe asthma undergoing dupilumab treatment in real-world settings. |
| DOI | 10.1016/j.alit.2024.08.005 |
| PMID | 39277433 |