ノグチ レイ   NOGUCHI Rei
  野口 玲
   所属   医学部 医学科
   職種   講師
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Establishment and characterization of NCC-OS2-C1: a novel patient-derived cell line of osteosarcoma.
掲載誌名 正式名:Human cell
略  称:Hum Cell
ISSNコード:17490774/09147470
掲載区分国外
巻・号・頁 38(3),pp.81
著者・共著者 Iwata Shuhei, Noguchi Rei, Osaki Julia, Adachi Yuki, Shiota Yomogi, Ogura Koichi, Nishino Shogo, Yoshida Akihiko, Ohtori Seiji, Kawai Akira, Kondo Tadashi
担当区分 2nd著者
発行年月 2025/04
概要 Osteosarcoma is the most common primary bone sarcoma with a bimodal age distribution. Complete surgical resection with neoadjuvant chemotherapy is the standard curative treatment, and no effective therapeutic strategy has been established for metastatic cases, resulting in poor prognosis. Osteosarcoma presents complex and heterogeneous clinical and molecular features, and no molecular-targeted drugs are available. Therefore, effective multidisciplinary treatment strategies are urgently required. Patient-derived cell lines are essential tools in basic and translational oncology. Considering the heterogeneity of the disease, we established a novel cell line, NCC-OS2-C1, using surgically resected tumor tissues from a patient with osteosarcoma. NCC-OS2-C1 cells demonstrated constant proliferation, spheroid formation, and invasion. In addition, we demonstrated that NCC-OS2-C1 is applicable for the high-throughput screening of drugs. Thus, NCC-OS2-C1 is a valuable tool for basic and translational research on osteosarcoma.
DOI 10.1007/s13577-025-01198-8
PMID 40169461