|
クロダ ハジメ
KURODA Hajime
黒田 一 所属 医学部 医学科（附属足立医療センター） 職種 教授 |
|
| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Prognostic impact of tumor-associated neutrophils in breast cancer. |
| 掲載誌名 | 正式名：International journal of clinical and experimental pathology 略 称：Int J Clin Exp Pathol ISSNコード：19362625/19362625 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 17(3),pp.51-62 |
| 著者・共著者 | Kakumoto Akinari†, Jamiyan Tsengelmaa, Kuroda Hajime*, Harada Oi, Yamaguchi-Isochi Tomomi, Baba Shogo, Kato Yasutaka, Nishihara Hiroshi, Kawami Hiroyuki |
| 担当区分 | 責任著者 |
| 発行年月 | 2024 |
| 概要 | OBJECTIVES:Neutrophils are the most common type of leukocyte in mammals and play an essential role in the innate immune system and anti-cancer responses. However, recent studies identified the presence of tumor-associated neutrophils (TANs) as a poor prognostic factor. The present study investigated whether relationships exist between TANs and the clinicopathological factors and genetic status of breast cancer.METHODS:A total of 196 breast cancer patients with sufficient biopsy, breast-conserving surgery, or mastectomy specimens between 2014 and 2021 in Hokuto Hospital were included.RESULTS:TANs were individually counted in the tumor stroma (TS) and tumor nest (TN). A higher density of TANs in both TS and TN correlated with tumor size (TS P = 0.010; TN P = 0.001), a high histological grade (TS P < 0.001; TN P < 0.001), the histological type (TS P = 0.009; TN P = 0.034), a high ratio of lymph node metastasis (TS P < 0.001; TN P < 0.001), an advanced stage of cancer (TS P < 0.001; TN P = 0.002), intrinsic subtypes (TS P < 0.001; TN P < 0.001), ERBB2 (TS P < 0.001; TN P < 0.001), MAP3K1 (TS P = 0.002; TN P = 0.023), and TP53 (TS P < 0.001; TN P < 0.001). A higher density of TANs in TS and TN also correlated with shorter disease-free survival and overall survival (P < 0.001).CONCLUSION:The present results suggest that a higher density of TANs correlates with unfavorable prognostic factors in breast cancer. Further research on clinicopathological and genetic factors associated with TANs in breast cancer is needed. |
| DOI | 10.62347/JQDQ1527 |
| PMID | 38577697 |