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タカヤマ ユキコ
TAKAYAMA Yukiko
高山 敬子 所属 医学部 医学科（東京女子医科大学病院） 職種 講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | 5-Fluorouracil metabolic pathway genes predict recurrence risk following adjuvant S-1 therapy: Results of an ancillary analysis from a phase III trial of resected biliary tract cancer (JCOG1202A1) |
| 掲載誌名 | 正式名：Journal of hepato-biliary-pancreatic sciences 略 称：J Hepatobiliary Pancreat Sci ISSNコード：18686982/18686974 |
| 掲載区分 | 国内 |
| 巻・号・頁 | 31(12),pp.886-896 |
| 著者・共著者 | MITSUNAGA Shuichi, IKEDA Masafumi, NOMURA Shogo, MORIZANE Chigusa, TODAKA Akiko, YAMAMOTO Naoto, KAMATA Ken, YANAGIBASHI Hiroo, MIZUNO Nobumasa, KAWAMOTO Yasuyuki, GOTOH Kunihito, SHIRAKAWA Hirofumi, OKANO Naohiro, NOMURA Tatsuya, TANAKA Kazunari, TAKAHASHI Amane, YAGI Shintaro, OHTA Koji, TAKAYAMA Yukiko, MIWA Haruo, NAGANO Hiroaki, KOJIMA Yasushi, HISANO Terumasa, TAHARA Munenori, SAKUMA Yasunaru, ARAI Hiroyuki, NAKAMURA Ikuo, KATAYAMA Hiroshi, KONISHI Masaru, UENO Makoto |
| 発行年月 | 2024/12 |
| 概要 | BACKGROUND:S-1, an oral fluoropyrimidine derivative, is standard adjuvant therapy for resected biliary tract cancer (BTC), based on the results of the JCOG1202, a phase III trial evaluating the survival benefit with adjuvant S-1 following curative resection for BTC compared to surgery alone. This multicenter ancillary study of the JCOG1202 aimed to evaluate the prognostic impact of the 5-fluorouracil (5-FU) metabolic pathway genes including thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD).METHODS:The 5-FU metabolic pathway genes were measured in tumor cells from formalin-fixed paraffin-embedded resected specimens from 183 patients (surgery alone: n = 94; adjuvant S-1: n = 89). We randomly divided them into training (n = 96) and validation sets (n = 87) for evaluating the interaction between gene levels and RFS benefits in the treatment arm.RESULTS:RFS benefits of adjuvant S-1 were observed in the low DPD (HR = 0.440 and 0.748, respectively in the training and validation sets) and the low TP groups (HR = 0.709 and 0.602, respectively). Clinicopathological characteristics were well balanced between low and high DPD populations. More advanced stage tumors were observed in high TP populations as compared to those in low TP populations (p = .0332).CONCLUSION:The results suggest the RFS benefit of adjuvant S-1 in resected BTC patients with low DPD and low TP gene expressions. |
| DOI | 10.1002/jhbp.12071 |
| PMID | 39318258 |