キクヤマ　マサタカ   KIKUYAMA Masataka   菊山　正隆    所属   医学部 医学科（東京女子医科大学病院）    職種   特任准教授
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Focal pancreatic parenchymal atrophy could be a precursor of pancreatic cancer
掲載誌名	正式名：Pancreatology 略　 称：Pancreatology ISSNコード：14243911/14243903
掲載区分	国外
巻・号・頁	25(2),pp.241-249
著者・共著者	KIKUYAMA Masataka, NAKAHODO Jun, CHIBA Kazuro, HONDA Goro
担当区分	筆頭著者
発行年月	2025/03
概要	BACKGROUND/OBJECTIVES:We previously reported that focal pancreatic parenchymal atrophy (FPPA) indicates high-grade pancreatic intraepithelial neoplasia (HG-PanIN) or carcinoma in situ (CIS). Because HG-PanIN progresses into pancreatic ductal adenocarcinoma (PDAC), the relationship between FPPA and PDAC should be investigated.METHODS:We included 54 patients with PDAC, whose previous computed tomography or magnetic resonance imaging were reviewed. The existence, positional relationship between FPPA and PDAC, and time between FPPA recognition and PDAC diagnosis were all examined. Of the 54 patients, 28 underwent surgery. The remaining 26 patients were histopathologically diagnosed with PDAC using endoscopic ultrasonography-guided fine needle aspiration.RESULTS:Among the 54 patients included, 49 (83.3 %) had FPPA. The pancreatic head and body were the common sites of FPPA. In all patients with FPPA, PDAC developed near the FPPA, with an average distance of 7.93 mm between the edge of the FPPA and the center of the PDAC. The interval between FPPA recognition and PDAC diagnosis was 35.33 months, which was significantly shorter in the surgical group.CONCLUSIONS:FPPA could be a precursor of PDAC and suggest the area at risk of PDAC.
DOI	10.1016/j.pan.2025.01.003
PMID	39894733