ナカイ　ヨウスケ   NAKAI Yousuke   中井　陽介    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	総説
言語種別	英語
査読の有無	査読なし
表題	Disconnected pancreatic duct syndrome: diagnostic and therapeutic challenges and future directions
掲載誌名	正式名：Expert review of gastroenterology & hepatology 略　 称：Expert Rev Gastroenterol Hepatol ISSNコード：17474132/17474124
掲載区分	国外
巻・号・頁	18(10),pp.631-645
著者・共著者	TAKENAKA Mamoru, SAITO Tomotaka, HAMADA Tsuyoshi, OMOTO Shunsuke, SHIOMI Hideyuki, IWASHITA Takuji, MASUDA Atsuhiro, MATSUBARA Saburo, MARUTA Akinori, IWATA Keisuke, MUKAI Tsuyoshi, ISAYAMA Hiroyuki, YASUDA Ichiro, NAKAI Yosuke
発行年月	2024/10
概要	INTRODUCTION:Disconnected pancreatic duct syndrome (DPDS) is a pathological condition that causes various symptoms due to the continuous secretion of pancreatic enzymes from the pancreas upstream, which has been separated due to disconnection of the pancreatic duct (DPD) for various reasons.Acute necrotizing pancreatitis includes a certain probability of DPDS appearance, which makes it necessary to provide various treatments for DPDS. Furthermore, DPDS can impact long-term results, such as recurrence and impaired pancreatic function. Although the development of various modalities has contributed to diagnosis and treatment, especially less invasive endoscopic therapy, DPDS is often overlooked, and the diagnosis can be delayed due to the lack of consensus on its definition and classification. This review summarizes the current knowledge and challenges of DPDS and discusses the optimal strategy for its diagnosis and treatment, as well as future perspectives.AREAS COVERED:Given the lack of established definition, diagnosis, and treatment of DPDS, we conducted a thorough review of the existing literature.EXPERT OPINION:It is emphasized that a standardized definition and classification of DPDS is essential for designing and conducting clinical studies to address current unmet needs in managing patients with DPDS.
DOI	10.1080/17474124.2024.2419056
PMID	39420546