ナカヤマ　マサミチ   NAKAYAMA Masamichi   中山　正道    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   講師
論文種別	総説
言語種別	英語
査読の有無	査読あり
招待の有無	招待あり
表題	Molecular design of dynamically thermoresponsive biomaterials
掲載誌名	正式名：Science and technology of advanced materials. 略　 称：Sci Technol Adv Mater ISSNコード：14686996/18785514
掲載区分	国外
巻・号・頁	26(1),pp.2475736
著者・共著者	KOBAYASHI Jun†*, NAKAYAMA Masamichi, NAGASE Kenichi
担当区分	2nd著者
発行年月	2025/03/24
概要	Dynamically thermoresponsive biomaterials, particularly those utilizing poly(N-isopropylacrylamide) (PNIPAAm), have attracted much attention in biomedical applications due to their reversible phase transition near body temperature. These biomaterials provide innovations across drug delivery system, chromatography, and tissue engineering. Molecular designs, such as the incorporation of hydrophilic comonomers or graft copolymers in PNIPAAm hydrogels, enhance rapid kinetics of the gels when jumping the temperature across the phase transition temperature, because of avoiding ‘skin layer’ formation on the surface of the gels. Nanocarriers possessing PNIPAAm coronas facilitate spatial drug delivery and temporally on-demand drug release to targeted cancers in combination with hyperthermic therapy. Downsizing of PNIPAAm hydrogels accelerates the kinetics of shrinkage/swelling, leading to applications as thermoresponsive chromatographic matrices and cell cultureware. PNIPAAm-modified surfaces support thermoresponsive cell culture systems for the non-invasive recovery of intact cell sheets, enabling advanced regenerative therapies and layered 3D tissue formation. Recent developments also integrate growth factor delivery for sustained cell stimulation on culturewares. Newly developed biomaterials, including dynamically thermoresponsive PNIPAAm, are expected to expand the opportunity for novel treatment technologies such as targeted therapies and regenerative medicine.
DOI	10.1080/14686996.2025.2475736