タニ　キミタカ   TANI Kimitaka   谷　公孝    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Comprehensive data of 5085 patients newly diagnosed with colorectal liver metastasis between 2013 and 2017: Fourth report of a nationwide survey in Japan
掲載誌名	正式名：Journal of hepato-biliary-pancreatic sciences 略　 称：J Hepatobiliary Pancreat Sci ISSNコード：18686982/18686974
掲載区分	国内
巻・号・頁	32(1),pp.26-43
著者・共著者	SAKAMOTO Katsunori, BEPPU Toru, HONDA Goro, KOTAKE Kenjiro, YAMAMOTO Masakazu, TAKAHASHI Keiichi, ENDO Itaru, HASEGAWA Kiyoshi, ITABASHI Michio, HASHIGUCHI Yojiro, KOTERA Yoshihito, KOBAYASHI Shin, YAMAGUCHI Tatsuro, KAWAI Kazushige, NATSUME Soichiro, TABUCHI Ken, KOBAYASHI Hirotoshi, YAMAGUCHI Kensei, TANI Kimitaka, MORITA Satoshi, AJIOKA Yoichi, MIYAZAKI Masaru, SUGIHARA Kenichi
発行年月	2025/01
概要	The Joint Committee for Nationwide Survey on colorectal liver metastasis (CRLM) was established to improve treatment outcomes in patients with CRLM. The aim of this study was to evaluate the transition in the characteristics and treatment strategies of patients with CRLM and to analyze the prognostic factors. The data of 5085 patients newly diagnosed between 2013 and 2017 were compared with those of 3820 patients from 2005 and 2007. In patients who underwent hepatectomy (n = 2759 and 2163), the number of CRLMs was significantly higher and in the 2013-2017 data than in the 2005-2007 data (median 2 vs. 1; p = .005). Overall survival (OS) rates after diagnosis of CRLM after hepatectomy were better in the 2013-2017 data than that in the 2005-2007 data (5-year OS, 62.4% vs. 56.7%, p < .001). Recurrence-free survival (RFS) after hepatectomy was comparable between the groups (5-year RFS, 30.5% vs. 30.7%; p = .068). Multivariate analyses identified age at diagnosis of CRLM ≥70 years, lymph node metastasis of primary lesion, preoperative carbohydrate antigen (CA) 19-9 value >100 U/mL, number of CRLM 2-4, and R2 resection as independent predictors of OS. Synchronous CRLM, concomitant extrahepatic metastasis, lymphatic invasion, lymph node metastasis of primary lesion, preoperative CA19-9 value >100 U/mL, number of CRLM 5-, and nonlaparoscopic approach were selected as that of RFS. Despite having a higher prevalence of advanced stage CRLM in the 2013-2017 patient population compared to the 2005-2007 cohort, prognostic outcomes demonstrably improved in the later period.
DOI	10.1002/jhbp.12078
PMID	39530296