イイヅカ　ユズル   IIDZUKA Yuzuru   飯塚　讓    所属   医学部 医学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Dietary coconut oil lowered circulating fetuin-A levels and hepatic expression of fetuin-A in ‍KK/‍TaJcl mice
掲載誌名	正式名：Journal of Clinical Biochemistry and Nutrition 略　 称：J Clin Biochem Nutr ISSNコード：09120009
掲載区分	国外
巻・号・頁	76(2),pp.131-138
著者・共著者	Iizuka Yuzuru†*, Kitagawa Chikako, Tamura Towa, Ueshiba Hidehiro, Hirako Satoshi, Osaka Toshifumi, Kim Hyounju, Yanagisawa Naoko
担当区分	筆頭著者,責任著者
発行年月	2025/03/01
概要	Although coconut oil has attracted great attention as a functional food, enough supportive scientific evidence is lacking. In addition, the beneficial effects of coconut oil consumption on the pre­vention of metabolic disorders are controversial. Fetuin-A is a plasma glycoprotein secreted by hepatocytes and adipocytes. Circulating fetuin-A levels relate to insulin resistance due to macrophage-mediated adipose tissue inflammation. This study demonstrated that coconut oil feeding significantly down­regulated the hepatic expression of fetuin-A and reduced its plasma level in KK ‍mice—an obese diabetic model animal. The expression of monocyte chemoattractant protein-1, a potent inducer for macro­phage infiltration, decreased in epididymal white adipose tissue in coconut oil-fed KK mice. The expression of CD68 and CD11c, markers of proinflammatory M1 macrophages, was significantly reduced by coconut oil feeding in epididymal white adipose tissue of KK mice. However, the mice did not exhibit improved insulin resistance. Our results may further support the potential of coconut oil as a dietary trigger that can ‍reduce both circulating fetuin-A levels and infiltration of proinflammatory macrophages in visceral adipose tissue.
DOI	10.3164/jcbn.24-160