イイダ　トモヒロ   IIDA Tomohiro
  飯田　知弘
   所属   医学部 医学科（東京女子医科大学病院）
   職種   客員教授
Article types Original article
Language English
Peer review Peer reviewed
Title One-year outcomes and safety assessment of faricimab in treatment-naïve patients with neovascular age-related macular degeneration in Japan.
Journal Formal name：Scientific reports
Abbreviation：Sci Rep
ISSN code：20452322/20452322
Domestic / ForeginForegin
Volume, Issue, Page 14(1),pp.11681
Author and coauthor Mukai Ryo, Kataoka Keiko, Tanaka Koji, Miyara Yasunori, Maruko Ichiro, Nakayama Makiko, Watanabe Yuto, Yamamoto Akiko, Wakatsuki Yu, Onoe Hajime, Wakugawa Sorako, Terao Nobuhiro, Hasegawa Taiji, Kawai Moeko, Maruko Ruka, Itagaki Kanako, Honjo Jyunichiro, Okada Annabelle A, Mori Ryusaburo, Koizumi Hideki, Iida Tomohiro, Sekiryu Tetsuju
Publication date 2024/05
Summary This multicentre retrospective study evaluated the 1-year outcomes and safety profile of faricimab in treatment-naïve patients with neovascular age-related macular degeneration (nAMD). Fifty-five patients (57 eyes) underwent loading therapy comprising three monthly faricimab injections. If dryness was achieved by the third month, subsequent treat-and-extend (TAE) follow-up continued at a minimum 8-week interval thereafter. If wet macula persisted at the third month, a fourth dose was administered, followed by the TAE regimen. After 1 year, improvements in visual acuity (0.44 ± 0.46 [baseline] to 0.34 ± 0.48; p < 0.01) and central foveal thickness (326 ± 149 [baseline] to 195 ± 82 μm; p < 0.0001) were significant. Dry macula, characterised by the absence of intraretinal or subretinal fluid, was achieved in 65% of cases. Treatment intervals varied, ranging from 8 to 16 weeks, with 44% of eyes extending to a 16-week interval, followed by 33% at 8 weeks, 16% at 12 weeks, 5% at 14 weeks, and 2% at 10 weeks. Notably, 50% of the polypoidal choroidal vasculopathy patients exhibited complete regression of polypoidal lesions between 12 and 15 months. Faricimab treatment in nAMD patients induced significant improvements in central vision and retinal morphology. Two cases of retinal pigment epithelial tears and one case of iritis were reported as ocular complications.
DOI 10.1038/s41598-024-62559-1
PMID 38778065