スズキ　ヤスユキ   SUZUKI Yasuyuki   鈴木　康之    所属   医学部 医学科（東京女子医科大学病院）    職種   臨床卓越教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Impact of preoperative bloodstream infection on outcomes of pediatric liver transplant recipients treated for acute liver failure.
掲載誌名	正式名：Transplant infectious disease : an official journal of the Transplantation Society 略　 称：Transpl Infect Dis ISSNコード：13993062/13982273
掲載区分	国外
巻・号・頁	26(1),pp.e14200
著者・共著者	Baba Chiaki, Funaki Takanori, Uranaka Makoto, Hashiya Mai, Ninagawa Jun, Sakamoto Seisuke, Kasahara Mureo, Nagasaka Yasuko, Suzuki Yasuyuki, Kasuya Shugo
発行年月	2024/02
概要	BACKGROUND:Acute liver failure (ALF) is a component of multisystem organ failure that causes severe liver dysfunction in patients without underlying chronic liver disease. The patients with ALF are prone to have infections, including bacteremia. However, studies of the infectious impact for post liver transplantation (LT) in pediatric ALF are limited. We aimed to evaluate our current practice for pediatric LT cases of ALF with preoperative bacteremia.METHODS:The records of all patients under 18 years old undergoing LT for ALF in our center from November 2005 to December 2021 were collected. They were divided into two groups: those with a preoperative bloodstream infection (BSI) and those without (NBSI). We compared the preoperative status and also reviewed the details of the BSI group. Intraoperative course and postoperative outcomes were also compared.RESULTS:There were 19 BSI patients and 66 NBSI patients. One BSI case was detected on the day of LT. This patient had no changes in vital signs and general condition. After evaluation and therapeutic intervention by pediatric infectious disease specialists, LT was performed on the same day. Five cases developed septic shock at the time of detection of BSI. All BSI patients were in stable condition on the operation day with proper interventions. There were no significant differences in mortality and hospital stay between both groups.CONCLUSIONS:LT might be able to be performed for pediatric ALF even with positive blood cultures. In addition, appropriate therapeutic intervention by specialists and patient's stable condition before LT are essential.
DOI	10.1111/tid.14200
PMID	38010711