ナガサカ　ヤスコ   NAGASAKA Yasuko   長坂　安子    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Pharmacological preconditioning with inhaled nitric oxide (NO): Organ-specific differences in the lifetime of blood and tissue NO metabolites.
掲載誌名	正式名：Nitric oxide : biology and chemistry 略　 称：Nitric Oxide ISSNコード：10898611/10898603
掲載区分	国外
巻・号・頁	80,pp.52-60
国際共著	国際共著
著者・共著者	Nagasaka Yasuko, Fernandez Bernadette O, Steinbicker Andrea U, Spagnolli Ester, Malhotra Rajeev, Bloch Donald B, Bloch Kenneth D, Zapol Warren M, Feelisch Martin
担当区分	筆頭著者
発行年月	2018/11
概要	Endogenous nitric oxide (NO) may contribute to ischemic and anesthetic preconditioning while exogenous NO protects against ischemia-reperfusion (I/R) injury in the heart and other organs. Why those beneficial effects observed in animal models do not always translate into clinical effectiveness remains unclear. To mitigate reperfusion damage a source of NO is required. NO inhalation is known to increase tissue NO metabolites, but little information exists about the lifetime of these species. We sought to investigate the fate of NO metabolites after breathing NO, and whether they reduce cardiac IR injury in mice.
DOI	10.1016/j.niox.2018.08.006
PMID	30114529