|
ホシノ ジユンイチ
HOSHINO Jiyun'ichi
星野 純一 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
|
| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Associations of anaemia and iron deficiency with health-related quality of life in patients with chronic kidney disease stage G3b-5 in Japan: sub analysis of the Reach-J CKD cohort study. |
| 掲載誌名 | 正式名：BMC nephrology 略 称：BMC Nephrol ISSNコード：14712369/14712369 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 25(1),pp.414 |
| 著者・共著者 | Okubo Reiko, Ohigashi Tomohiro, Kondo Masahide, Tsunoda Ryoya, Kai Hirayasu, Saito Chie, Hoshino Junichi, Okada Hirokazu, Narita Ichiei, Maruyama Shoichi, Wada Takashi, Yamagata Kunihiro |
| 発行年月 | 2024/11/19 |
| 概要 | BACKGROUND:Iron deficiency is a major contributor to anaemia in chronic kidney diseases. The association of anaemia and iron deficiency with health-related quality of life in Japanese patients with non-dialysis chronic kidney disease has not been examined. In this study, we evaluated anaemia and iron deficiency in patients with chronic kidney disease G3b-5 and examined their associations with health-related quality of life.METHODS:This nationwide cohort study included 2,249 patients with advanced chronic kidney disease receiving nephrologist care from 31 representative facilities throughout Japan; they were randomly selected through stratification by region and facility size and aligned with the Chronic Kidney Disease Outcomes and Practice Patterns Study. Using baseline patient data, we assessed the association of anaemia and iron deficiency with health-related quality of life, employing the 36-item Kidney Disease Quality of Life Questionnaire.RESULTS:The mean mental and physical component summary scores for all patients were 49 and 47, respectively. Patients with haemoglobin levels < 10 g/dL had worse three kidney disease subscale, mental component summary, physical component summary, and subdomain scores than those with haemoglobin levels > 12 g/dL. Patients with absolute iron deficiency (TSAT < 20% and ferritin < 100 ng/mL) had worse three kidney disease subscale and mental component summary scores than those with functional iron deficiency (TSAT < 20% and ferritin ≥ 100 ng/mL).CONCLUSIONS:Japanese patients with chronic kidney disease G3b-5 with anaemia or absolute iron deficiency had worse health-related quality of life. Our results provide clinical evidence of renal anaemia in Japan and will be useful for international comparisons. |
| DOI | 10.1186/s12882-024-03849-8 |
| PMID | 39563222 |