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ワカバヤシ ヒデタカ
WAKABAYASHI Hidetaka
若林 秀隆 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Masseter Muscle Volume and Its Association with Sarcopenia and Muscle Determinants in Older Japanese Adults: the Bunkyo Health Study. |
| 掲載誌名 | 正式名：Archives of medical research 略 称：Arch Med Res ISSNコード：18735487/01884409 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 56(1),pp.103095 |
| 著者・共著者 | Abudurezake Abulaiti, Kakehi Saori, Umemura Futaba, Kaga Hideyoshi, Someya Yuki, Tabata Hiroki, Yoshizawa Yasuyo, Naito Hitoshi, Tajima Tsubasa, Ito Naoaki, Otsuka Hikaru, Shi Huicong, Sugimoto Mari, Sakamoto Shota, Muroga Yukiko, Wakabayashi Hidetaka, Kawamori Ryuzo, Watada Hirotaka, Tamura Yoshifumi |
| 発行年月 | 2024/10 |
| 概要 | AIM:Sarcopenia has been with a decrease in masseter muscle (MM) thickness in high-risk older populations. However, the relationship between sarcopenia and determinants of MM volume (MMV) in the general elderly population remains unclear.METHOD:In a cross-sectional study of 1,484 older adults in Tokyo, we evaluated MMV using 3D MRI scanning, appendicular skeletal muscle mass (ASMM), handgrip strength, dietary intake, smoking, insulin-like growth factor 1 (IGF-1) levels, and the ACTN3 R577X polymorphism. Participants were divided into quintiles based on MMV (Q1-5).RESULTS:Participants in our study had a mean age of 73.0 ± 5.3 years and their MMV (Men: 35.3 ± 7.8 mL, Women: 25.0 ± 5.1 mL) was significantly higher in men than in women. A significant association between MMV and sarcopenia was observed, with the lowest quintile (Q1) showing a higher risk compared to the highest quintile (Q5) in both sexes. Body mass index (BMI) and age were independent determinants of ASMM in both sexes, whereas BMI, but interestingly not age, was a determinant of MMV. Moreover, IGF-1 was positively correlated with MMV in both sexes; smoking was negatively correlated with MMV in women. The ACTN3 577XX genotype was only associated with smaller MMV in men.CONCLUSION:Low MMV increased the risk of sarcopenia, particularly in men. BMI and age strongly influenced ASMM, while MMV was only weakly associated with BMI and not with age. Notably, IGF-1 level was positively associated with MMV only, and ACTN3 genotype was associated to reduced MMV only in men. |
| DOI | 10.1016/j.arcmed.2024.103095 |
| PMID | 39405919 |