キタハラ　シユウジ   Kitahara Shiyuuji   北原　秀治    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   特任准教授
論文種別	その他
言語種別	英語
査読の有無	査読なし
表題	A tumor microenvironment-based classification of gastric cancer for more effective diagnosis and treatment.
掲載誌名	正式名：Research square 略　 称：Res Sq ISSNコード：26935015/26935015
掲載区分	国外
巻・号・頁	pp.0-0
国際共著	国際共著
著者・共著者	Duda Dan, Dima Simona, Sorop Andrei, Kitahara Shuji, Setia Namrata, Chivu-Economescu Mihaela, Matei Lilia, Herlea Vlad, Pechianu Nicolae, Inomata Takenori, Matsui Aya, Khachatryan Anna, Aoki Shuichi, Lauwers Gregory, Popescu Irinel
発行年月	2023/08
概要	With approximately one million diagnosed cases and over 700,000 deaths recorded annually, gastric cancer (GC) is the third most common cause of cancer-related deaths worldwide. GC is a heterogeneous tumor. Thus, optimal management requires biomarkers of prognosis, treatment selection, and treatment response. The Cancer Genome Atlas program sub-classified GC into molecular subtypes, providing a framework for treatment personalization using traditional chemotherapies or biologics. Here, we report a comprehensive study of GC vascular and immune tumor microenvironment (TME)-based on stage and molecular subtypes of the disease and their correlation with outcomes. Using tissues and blood circulating biomarkers and a molecular classification, we identified cancer cell and tumor archetypes, which show that the TME evolves with the disease stage and is a major determinant of prognosis. Moreover, our TME-based subtyping strategy allowed the identification of archetype-specific prognostic biomarkers such as CDH1-mutant GC and circulating IL-6 that provided information beyond and independent of TMN staging, MSI status, and consensus molecular subtyping. The results show that integrating molecular subtyping with TME-specific biomarkers could contribute to improved patient prognostication and may provide a basis for treatment stratification, including for contemporary anti-angiogenesis and immunotherapy approaches.
DOI	10.21203/rs.3.rs-3089359/v1
PMID	37577519