ワコウ　シヨウ   WAKOU Shiyou   若生　翔    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Characteristic cerebrospinal fluid findings in immune checkpoint inhibitor-related peripheral neuropathy: A case report.
掲載誌名	正式名：Journal of neuroimmunology 略　 称：J Neuroimmunol ISSNコード：18728421/01655728
掲載区分	国外
巻・号・頁	374,pp.578010
著者・共著者	Sho Wako 1, Ryotaro Ikeguchi 2, Kunio Toda 1, Masaki Kobayashi 1, Ryujin Miyata 3, Hidekazu Kuramochi 4, Atsuhiro Ichihara 5, Yuko Shimizu 1, Kazuo Kitagawa 1
発行年月	2023/01
概要	Although immune checkpoint inhibitors (ICIs) are widely used to treat unresectable malignant tumors, they can cause undesirable side effects called immune-related adverse events, including neurological toxicities. Here, we describe a case of ICI-related peripheral neuropathy (irPN) with characteristic cerebrospinal fluid (CSF) findings. In addition to pleocytosis and increased protein levels, the present case showed increased levels of CSF soluble interleukin-2 receptor (sIL-2R), IL-6, and IL-10, suggesting activated T cell-related autoimmunity. We believe that CSF cytokines and sIL-2R could be novel biomarkers of irPN.
DOI	10.1016/j.jneuroim.2022.578010
PMID	36508929