ナカミゾ　ムネナガ   NAKAMIZO Munenaga   中溝　宗永    所属   医学部 医学科（東京女子医科大学病院）    職種   特任教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Survival Outcome Superiority of Total Pharyngolaryngectomy Compared with Chemoradiotherapy for T4aM0 Hypopharyngeal Squamous Cell Carcinoma: A Nationwide Database Study of Japan
掲載誌名	正式名：Annalus of Surgical Oncology 略　 称：ASO ISSNコード：1534-9265
掲載区分	国外
巻・号・頁	31(12),pp.8206-8213
著者・共著者	OMURA Go, EGUCHI Kohataro, YOSHIMOTO Seiichi, HONMA Yoshitaka, FUSHIMI Chihiro, SAKAI Toshihiko, MATSUMOTO Yoshifumi, SAKAI Azusa, KITAYAMA Megumi, KAWAKITA Daisuke, KIRITA Tadaaki, KODAIRA Takeshi, NAKAMIZO Munenaga, NIBU Ken-ichi
発行年月	2024/11
概要	BACKGROUND:The purpose of this study is to elucidate whether total pharyngolaryngectomy (TPL) or chemoradiotherapy (CRT) provides a better prognostic outcome in patients with T4aM0 hypopharyngeal carcinoma (HPSCC) using a nationwide database.METHODS:All data were obtained from the Head and Neck Cancer Registry of Japan, and information from patients who were newly diagnosed with T4aM0 HPSCC between 2011 and 2015 was extracted. The primary endpoint was disease-specific survival (DSS), and the secondary endpoint was overall survival (OS). The inverse probability of treatment weighting (IPTW) adjustments was used for survival analyses.RESULTS:Our cohort included 1143 patients. The TPL and CRT groups included 724 and 419 patients, respectively. Following IPTW adjustments, both the OS and DSS of the TPL group were significantly longer than those of the CRT group (P = .02 and P = .002, respectively).CONCLUSIONS:Survival superiority was demonstrated for patients with T4aM0 HPSCC treated with TPL compared with those treated with CRT.
DOI	https://doi.org/10.1245/s10434-024-15994-3
PMID	39133449