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ホシノ ジユンイチ
Hoshino Jiyun'ichi
星野 純一 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Dapagliflozin treatment in patients with chronic kidney disease associated with autosomal dominant polycystic kidney disease. |
| 掲載誌名 | 正式名：Clinical kidney journal 略 称：Clin Kidney J ISSNコード：20488505/20488505 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 17(8),pp.sfae186 |
| 著者・共著者 | Yoshimoto Masatoshi, Sekine Akinari, Suwabe Tatsuya, Oba Yuki, Mizuno Hiroki, Yamanouchi Masayuki, Ubara Yoshifumi, Hoshino Junichi, Inoue Noriko, Tanaka Kiho, Hasegawa Eiko, Sawa Naoki, Wada Takehiko |
| 発行年月 | 2024/06/18 |
| 概要 | INTRODUCTION:The DAPA-CKD study showed a protective effect of dapagliflozin on kidney function in chronic kidney disease (CKD) patients with and without diabetes mellitus. Although dapagliflozin is expected to be effective also in CKD patients with autosomal dominant polycystic kidney disease (ADPKD), its efficacy and safety in this population remain unknown because ADPKD was an exclusion criterion in the DAPA-CKD study. Therefore, we evaluated the effects of dapagliflozin in CKD patients with ADPKD.METHODS:We performed a retrospective observational study of seven patients with ADPKD treated with dapagliflozin at Toranomon Hospital, Tokyo, Japan. We analyzed changes in estimated glomerular filtration rate (eGFR) slope and annual height-corrected total kidney volume before and after starting dapagliflozin treatment.RESULTS:The median observation period after starting dapagliflozin was 20 months. Four patients received concomitant tolvaptan. The eGFR slope before and after initiation of dapagliflozin could be calculated in six patients and improved in all of them except the one who did not receive a renin-angiotensin system (RAS) inhibitor. Annual height-corrected total kidney volume increased in all patients. Concurrent tolvaptan treatment had no effect.CONCLUSION:In CKD patients with ADPKD, dapagliflozin may increase kidney volume but may have a protective effect on kidney function when used concomitantly with RAS inhibitors. |
| DOI | 10.1093/ckj/sfae186 |
| PMID | 39099568 |