マナベ　シユン   Manabe Shiyun
  眞部　俊
   所属   医学部 医学科（東京女子医科大学病院）
   職種   講師
論文種別 原著
言語種別 英語
査読の有無 査読なし
表題 Factors associated with early-onset intracranial aneurysms in patients with autosomal dominant polycystic kidney disease.
掲載誌名 正式名：Journal of nephrology
略　 称：J Nephrol
ISSNコード：17246059/11218428
掲載区分国外
巻・号・頁 37(4),pp.983-992
著者・共著者 Ushio Yusuke, Kataoka Hiroshi, Akagawa Hiroyuki, Sato Masayo, Manabe Shun, Kawachi Keiko, Makabe Shiho, Akihisa Taro, Seki Momoko, Teraoka Atsuko, Iwasa Naomi, Yoshida Rie, Tsuchiya Ken, Nitta Kosaku, Hoshino Junichi, Mochizuki Toshio
発行年月 2024/05
概要 BACKGROUND:Recently, the importance of attribute-based medicine has been emphasized. The effects of early-onset intracranial aneurysms on patients can be significant and long-lasting. Herein, we compared the factors associated with intracranial aneurysms in patients with autosomal dominant polycystic kidney disease (ADPKD) according to age categories (≥ 50 years, < 50 years).
RESULTS:Regarding the presence of intracranial aneurysm, significant interactions were identified between the age category (age ≥ 50 years), female sex (P = 0.0027 for the interaction) and hypertension (P = 0.0074 for the interaction). Female sex and hypertension were associated with intracranial aneurysm risk factors only in patients aged ≥ 50 years. The presence of intracranial aneurysm was significantly associated with chronic kidney disease (CKD) stages 4-5 (odds ratio [OR] = 3.87, P = 0.0007) and family history of intracranial aneurysm or subarachnoid hemorrhage (OR = 2.30, P = 0.0217) in patients aged < 50 years. For patients aged ≥ 50 years, in addition to the abovementioned factors [OR = 2.38, P = 0.0355 for CKD stages 4-5; OR = 3.49, P = 0.0094 for family history of intracranial aneurysm or subarachnoid hemorrhage], female sex (OR = 4.51, P = 0.0005), and hypertension (OR = 5.89, P = 0.0012) were also associated with intracranial aneurysm.
CONCLUSION:Kidney dysfunction and family history of intracranial aneurysm or subarachnoid hemorrhage are risk factors for early-onset intracranial aneurysm. Patients aged < 50 years with a family history of intracranial aneurysm or subarachnoid hemorrhage or with CKD stages 4-5 may be at an increased risk of early-onset intracranial aneurysm.
DOI 10.1007/s40620-023-01866-8
PMID 38315279