イシヅカ　ツトム   Ishizuka Tsutomu   石塚　敏    所属   その他 その他    職種   臨床検査副技師長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Kidney transplantation in a recipient with anti-HLA antibody IgM positive.
掲載誌名	正式名：Transplant immunology 略　 称：Transpl Immunol ISSNコード：18785492/09663274
掲載区分	国外
巻・号・頁	21(3),pp.150-4
著者・共著者	Suzuki Mari, Ishida Hideki, Komatsu Tomonori, Kennoki Takafumi, Ishizuka Tsutomu, Tanabe Kazunari
発行年月	2009/07
概要	In general, anti-HLA antibody belongs to the IgG subclass, but there are very few reports of detection of anti-HLA IgM antibodies. In the present study, we report a renal transplant recipient with a positive NIH-complement dependent cytotoxicity (NIH-CDC) test. The patient was a 24-year-old male with focal segmental glomerulosclerosis (FSGS) as the underlying kidney disease. He had been on maintenance hemodialysis since December 2003 and finally received a living-donor allograft from his mother in October 2008. Pre-transplantation, the NIH-CDC test was positive for both B and T cells, but the flow-cytometric crossmatch test (FCXM) was negative for both cells. The result of the panel-reactive antibody assay (PRA)-single beads test using anti-IgM antibody as the second antibody demonstrated that the positive NIH-CDC test was due to the presence of anti-HLA IgM antibody against the donor-specific antigen A24. Biopsy specimens showed thrombus formation in a small number of glomeruli immediately after the transplantation, but this finding was no longer seen at three months postoperatively. We report successful renal transplantation in a case with anti-HLA IgM antibody.
DOI	10.1016/j.trim.2009.03.005
PMID	19356741